IPO.ah.7

(redirected from importin-7)

IPO.ah.7

A gene on chromosome 11p15.4 that encodes one of the approximately 20 potential Ran targets that share a sequence motif related to the Ran-binding site of importin-beta. Like importin-beta, IPO7 prevents the activation of Ran’s GTPase by RanGAP1 and inhibits nucleotide exchange on RanGTP; it also binds directly to nuclear pore complexes, where it competes for binding sites with importin-beta and transportin.
References in periodicals archive ?
However, whether the NLS1 sequence, to which these importins bind, is the same or different is not very well understood [55] even though the presence of both NLS1 and NLS2 on GR and its binding to importin-7 has been found in nonmammalian cells, suggesting the crucial role of both NLSs for translocation of GR into nucleus [55].
Usmani, "Importin-7 mediates glucocorticoid receptor nuclear import and is impaired by oxidative stress, leading to glucocorticoid insensitivity," FASEB Journal, vol.