IPO.af.5

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IPO.af.5

A gene on chromosome 13q32.2 that encodes the beta chain of the importin family of heterodimeric receptors, which import proteins into the nucleus. It is thought to mediate docking of the importin/substrate complex to the nuclear pore complex by binding to nucleoporin; the complex is then translocated through the pore by an energy-requiring, Ran-dependent mechanism.
References in periodicals archive ?
79), a GWAS with 785 cases and 3383 controls in a Japanese population identified 3 novel PAD susceptibility loci at importin-5 (IPO5)/RAS-related protein 2A, endothelin receptor type A, and histone deacetylase 9.