IPO.ae.4

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IPO.ae.4

A gene on chromosome 14q12 that encodes a receptor that imports proteins into the nucleus. It is thought to mediate docking of the importin/substrate complex to the nuclear pore complex by binding to nucleoporin; the complex is then translocated through the pore by an energy-requiring, Ran-dependent mechanism.
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They regulate the interaction between H3/H4 and Importin-4, a nuclear transport receptor, in addition to the well-known-histone chaperone anti-silencing function 1 (ASF1).