IPO.ai.8

(redirected from importin 8)

IPO.ai.8

A gene on chromosome 12p11.21 that encodes one of the approximately 20 potential Ran targets that share a sequence motif related to the Ran-binding site of importin-beta. IPO8 binds to the nuclear pore complex and, with RanGTP and RANBP1, inhibits the GAP stimulation of Ran GTPase. Importin 8 is thought to play a role in nuclear protein import, either by acting as autonomous nuclear transport receptor or as an adapter-like protein in association with the importin-beta subunit KPNB1.
References in periodicals archive ?
Ivacevic et al., "Importin 8 is a gene silencing factor that targets argonaute proteins to distinct mRNAs," Cell, vol.
Fried, "Signal recognition particle protein 19 is imported into the nucleus by importin 8 (RanBP8) and transportin," Journal of Cell Science, vol.
(287-289) Proteomic analysis has also shown association of NPMALK with molecules involved in DNA repair (Ku86, Ku70, PARP1 [poly(ADP-ribose) polymerase 1], MSH2, PCNA [proliferating cell nuclear antigen], and MCM6 [mini-chromosome maintenance deficient 6 homolog]) (283) and has revealed other new binding partners for NPM-ALK, including Nup98 and importin 8 (subcellular protein transport), Stim 1 (calcium signaling), and 82FIP (RNA regulation).