IPO.ae.4

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IPO.ae.4

A gene on chromosome 14q12 that encodes a receptor that imports proteins into the nucleus. It is thought to mediate docking of the importin/substrate complex to the nuclear pore complex by binding to nucleoporin; the complex is then translocated through the pore by an energy-requiring, Ran-dependent mechanism.
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It is also possible that FA forms adducts with amino acid residues of histone chaperones, such as CAF-1, HIRA and ASF1, as well as with histone translocator proteins, such as Importin 4. This protein interaction could influence their expression or interfere with their activities.