importin


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importin

a protein involved in transporting molecules into the NUCLEUS.
References in periodicals archive ?
Importin is involved in nuclear import and export processes transporting other proteins intro nucleus by binding to nuclear localization signal (NLS) motifs (Tran et al., 2014).
Using genetically engineered mice, they identified importin alpha-5 as the transporter protein that helps MeCP2 to enter the brain cell nucleus.
Importin [alpha]: functions as a nuclear transport factor and beyond Masahiro OKA and Yoshihiro YONEDA Communicated by Shizuo AKIRA, M.J.A.
Furthermore, it has been reported that importin [alpha] and [beta] (IMP [alpha]/[beta]) are responsible for GHR nuclear translocation [4].
Frolova, "Venezuelan equine Encephalitis virus capsid protein forms a tetrameric complex with CRM1 and importin [alpha]/[beta] that obstructs nuclear pore complex function," Journal of Virology, vol.
It is also possible that FA forms adducts with amino acid residues of histone chaperones, such as CAF-1, HIRA and ASF1, as well as with histone translocator proteins, such as Importin 4.
Coat proteins of Rice tungro bacilliform virus and Mungbean yellow mosaic virus contain multiple nuclear-localization signals and interact with importin a.
Efficient nuclear transport via polycationic NLSs involves high affinity recognition by members of the importin (IMP) superfamily of nuclear transport molecules [32-34].
Teng, "Importin KPNA2 is required for proper nuclear localization and multiple functions of NBS1," The Journal of Biological Chemistry, vol.
Ivacevic et al., "Importin 8 is a gene silencing factor that targets argonaute proteins to distinct mRNAs," Cell, vol.
2) Proline-tyrosine-NLS (PY-NLS), characterized by a pro-line-tyrosine AA domain in the N-terminal, which allows the protein to bind to importin [beta]2 (also known as transportin or karyopherin [beta]2), and then relocates the cargo protein into the nucleus (15).
Indeed, STAT phosphorylation permits the dimerization of other STATs, culminating with the translocation to the nucleus mediated by importin a-5 and the Ran nuclear import system.