immunotoxin


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immunotoxin

(ĭm′yə-nō-tŏk′sĭn, ĭ-myo͞o′-)
n.
A hybrid molecule formed by binding a toxin to a monoclonal antibody, used to destroy tumor cells.

immunotoxin

an antibody attached to a specific toxic agent that is used to destroy specific cancer cells. Although experimental at present, these so-called ‘magic bullets’ hold out great hope as a new form of cancer CHEMOTHERAPY.
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Moreover, it signals with high constitutive activity [29, 30] and undergoes constitutive ligand-independent receptor internalization [31], a feature well suited for immunotoxin delivery.
Novel Chemokine-Based Immunotoxins for Potent and Selective Targeting of Cytomegalovirus Infected Cells
Lee, "Effect of antigen shedding on targeted delivery of immunotoxins in solid tumors from a mathematical model," PLoS ONE, vol.
Tumor-Shed Antigen Affects Antibody Tumor Targeting: Comparison of Two [sup.89]Zr-Labeled Antibodies Directed against Shed or Nonshed Antigens
Finally, the resulted immunotoxin with His-tag was purified through immobilized metal ion affinity chromatography (IMAC) using Ni-NTA purification resin and was verified by SDS-PAGE.
EGFR-Targeted Immunotoxin Exerts Antitumor Effects on Esophageal Cancers by Increasing ROS Accumulation and Inducing Apoptosis via Inhibition of the Nrf2-Keap1 Pathway
One of the biggest challenges for immunotoxin therapy is its potential immunogenicity, which can originate from either antibody part or toxin part.[sup][16] To avoid the generation of host anti-murine antibodies against the antibody part of an immunotoxin, this part can be further humanized or replaced by a fully human counterpart.[sup][22] As for the more immunogenic toxin domain, it can be reengineered by combining mutations that decrease lymphocyte epitopes to significantly minimize the immunogenicity induced by a foreign toxin protein.[sup][23] Immunotoxins with mutations at both B- and T-cell epitopes can theoretically eliminate the issue of immunogenicity.
Immunotoxin Therapy for Lung Cancer
The left eye of each animal was intravitreally injected with different doses of immunotoxin melanopsin-SAP (2 [micro]l/eye) (Advanced Targeting Systems, San Diego, CA, USA), consisting of saporin conjugated to a melanopsin polyclonal antibody.
Regulation of Reentrainment Function Is Dependent on a Certain Minimal Number of Intact Functional ipRGCs in rd Mice
Kreitman, "Immunotoxin therapy of cancer," Nature Reviews Cancer, vol.
Recombinant Immunotoxin Therapy of Glioblastoma: Smart Design, Key Findings, and Specific Challenges
(2001) Lowering the isoelectric point of the Fv portion of recombinant immunotoxins leads to decreased nonspecific animal toxicity without affecting antitumor activity.
Development of novel drug delivery systems using phage display technology for clinical application of protein drugs
The scientists found that, compared to antiretrovirals alone, the addition of the immunotoxin significantly reduced both the number of HIV-infected cells producing the virus in multiple organs and the level of HIV in the blood.
New toxin can kill lurking HIV-infected cells
Moreover, lintuzumab conjugated with immunotoxin recombinant gelonin (HUM-195/rGEL) has been under investigation in patients with relapsed/refractory myeloid leukemias [108].
Target therapy in hematological malignances: new monoclonal antibodies
Karande, "Abrin immunotoxin: targeted cytotoxicity and intracellular trafficking pathway," PloS ONE, vol.
Lead screening for HIV of C-C chemokine receptor type 5 receptor inhibited by traditional Chinese medicine
Using saporin-conjugated antidopamine hydroxylase (DSAP), a selective immunotoxin that destroys NE and epinephrine (E) containing neurons, loss of NE/E input in the arcuate nucleus resulted in an increase in baseline levels of neuropeptide Y/agouti-related peptide (NPY/AgRP) mRNA expression.
High-fat diet-induced alterations in the feeding suppression of low-dose nisoxetine, a selective norepinephrine reuptake inhibitor
Additionally, multiple INDs are expected in the next 12-24 months resulting from preclinical and discovery work underway to advance multiple antibody, immunotoxin, and protein decoy candidates, systemic delivery and a next generation RheoSwitch Therapeutic System(R).
ZIOPHARM Oncology Presents Preclinical Data at AACR Meeting

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