Immuno-oncology research has supported the fact that immunity system can effectively identify tumors and can stop or control long term growth of the same through immunosurveillance
. However, cancer progression leads to suppression of immunity systems natural functioning wherein immune-oncology therapies play an important role.
It also resolves a 'constitutional isomer issue' that arose following the publication in Angewandte Chemie International Edition entitled 'Pharmacophore Reassignment for Induction of the Immunosurveillance
Cytokine TRAIL' in May 2014.
Ectopic CD137 expression facilitates the escape of Hodgkin and Reed-Sternberg cells from immunosurveillance
The TGF[beta] plays a role in suppression of tumor immunosurveillance
via inhibition of T cell proliferation, which was perhaps best demonstrated by the use of transgenic T cell that had been rendered insensitive to the effects of TGF[beta] by transgenic expression of a dominant negative TGF[beta] type II receptor (dn TGF[beta]-RII), which has no signal transduction capabilities (87).
The Immunobiology of Cancer Immunosurveillance
Pouliquen has further mentioned that stromal cells are involved in immune escape and how the last two decades of immune-oncology research have demonstrated that tumour development can be controlled or stopped through immunosurveillance
Although both innate and adaptive immune systems play a crucial role in immunosurveillance
, mutated or genetically modified cells can develop numerous immunomodulatory strategies that allow them to evade or withstand antitumor immune responses.
These cells are the product of a process mediated by our own immune system referred to as Immunosurveillance
The concept of cancer immunosurveillance
was introduced by Burnet in 1957 and served as a starting point for the more recent cancer immunoediting approach.
Microbiome therapy is also used as gut bacteria can influence the responses to cancer immunotherapy, increase chemotherapy effectiveness, and modulate anticancer immunosurveillance
Clinical cure of HIV is a goal which has evaded researchers for a number of reasons, including the high genetic diversity of the HIV virus, the inability of PLWH to mount effective, HIV-specific antiviral immune responses and the ability of integrated HIV to persist in a latent form that escapes immunosurveillance
but is capable of reestablishing infection upon ART interruption.
In a study published in the Proceedings of the National Academy of Sciences, the researchers proposed an "immunosurveillance
hypothesis," positing that cancer cells are always popping up in the body but that T cells are typically able to get rid of them before they can form into a tumor.