immunosuppression


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Related to immunosuppression: Immunosuppressive drugs

immunosuppression

 [im″u-no-sŭ-presh´un]
inhibition of the immune response to unfamiliar antigens that may be present; used in transplantation procedures to prevent rejection of the transplant or graft, and in autoimmune disease, allergy, multiple myeloma, and other conditions.

im·mu·no·sup·pres·sion

(im'yū-nō-sū-presh'ŭn),
Prevention or interference with the development of immunologic response; may reflect natural immunologic unresponsiveness (tolerance), may be artificially induced by chemical, biologic, or physical agents, or may be caused by disease.

immunosuppression

(ĭm′yə-nō-sə-prĕsh′ən, ĭ-myo͞o′-)
n.
Suppression of the immune response, as by drugs or radiation, in order to prevent the rejection of grafts or transplants or to control autoimmune diseases. Also called immunodepression.

im′mu·no·sup·pres′sant (-prĕs′ənt) n.
im′mu·no·sup·pressed′ (-prĕst′) adj.
im′mu·no·sup·pres′sive adj.

Immunosuppression

Techniques to prevent transplant graft rejection by the body's immune system.

im·mu·no·sup·pres·sion

(im'yū-nō-sŭ-presh'ŭn)
Prevention or interference with the development of immunologic response; may reflect natural immunologic unresponsiveness, may be artificially induced by chemical, biologic, or physical agents, or caused by disease.
References in periodicals archive ?
Talaris Therapeutics, Inc., formerly Regenerex, is a late-clinical stage biotechnology company that is developing transformative cell therapies with the potential to eliminate the burden of chronic immunosuppression for organ transplant recipients as well as induce durable remissions in patients with severe auto-immune and immune-mediated disorders.
Targeting of B and T lymphocyte associated (BTLA) prevents graft-versus-host disease without global immunosuppression. J Exp Med 2010;207:2551-9.
In the study, 42.8% of the children with PTLD had been treated with reduced immunosuppression and rituximab, and 15.3% had received chemotherapy.
Due to intercurrent infection (fever (>39[degrees]C) with signs of otitis media and urinary tract infection (E.faecalis and Proteus mirabilis)), no changes to the immunosuppression were made at this time.
Reduction in immunosuppression did not alter the course and the patient expired.
Immunosuppression as well as neutrophil depletion with either anti-Gr-1 or anti-Ly6G significantly reduced the number of conducting airway wall neutrophils in noninfected mice compared to their respective control-treated animals (Figure 4(d)).
However, the report also documents a series of setbacks including eight rejections of the hands, which were managed with immunosuppression drugs.
This finding suggests that affected patients have a high net state of immunosuppression. Prior cytomegalovirus infection, the most common opportunistic infection in the study, might have had an immunomodulatory effect that made patients more likely to show development of a second opportunistic infection.
Cyclophosphamide-induced myelosuppression, immunosuppression, and oxidative stress lead to significant morbidity and mortality [5, 18-22].
It also lessens UV-caused immunosuppression. Ultraviolet radiation damage is the main cause of premalignant actinic keratoses as well as basal-cell carcinomas and squamous-cell carcinomas.
Oral candidiasis caused by Candida albicans are essentially presented in HIV/AIDS patients and considered as the marker of immunosuppression and disease progression.1
Breathing in 40 to 60 percent oxygen as opposed to the 21 percent oxygen in air can weaken immunosuppression and awaken antitumour cells, BBC health reported.