immunoproliferative small intestinal disease

Also found in: Acronyms.

im·mu·no·pro·lif·er·a·tive small in·tes·ti·nal dis·ease

diffuse lymphoplasmacytic infiltration of the proximal small bowel mucosa and mesenteric lymph nodes resulting in diarrhea, weight loss, abdominal pain, and clubbing of fingers and toes; seen in poor people in developing countries.
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immunoproliferative small intestinal disease



A rare mucosal lymphoma of the small intestine, associated with infection with Campylobacter jejuni. In this disease the small intestine fills with plasma cells that secrete an incomplete immunoglobulin, one in which an alpha heavy chain of the immunoglobulin molecule is formed without an associated light chain. Synonym: Mediterranean lymphoma; alpha heavy chain disease
Medical Dictionary, © 2009 Farlex and Partners
References in periodicals archive ?
Studies of archival biopsy specimens from six patients with untreated immunoproliferative small intestinal disease found C.
jejuni instead may play a secondary part in immunoproliferative small intestinal disease by persistently residing and "fostering disease only in hosts with preexisting abnormalities of the immune response of the gut."