immunoproliferative small intestinal disease
Also found in: Acronyms.
im·mu·no·pro·lif·er·a·tive small in·tes·ti·nal dis·ease
diffuse lymphoplasmacytic infiltration of the proximal small bowel mucosa and mesenteric lymph nodes resulting in diarrhea, weight loss, abdominal pain, and clubbing of fingers and toes; seen in poor people in developing countries.
Synonym(s): Mediterranean lymphoma
immunoproliferative small intestinal disease
,IPSID
A rare mucosal lymphoma of the small intestine, associated with infection with Campylobacter jejuni. In this disease the small intestine fills with plasma cells that secrete an incomplete immunoglobulin, one in which an alpha heavy chain of the immunoglobulin molecule is formed without an associated light chain. Synonym: Mediterranean lymphoma; alpha heavy chain disease