immunomodulatory drug


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immunomodulatory drug

Clinical pharmacology A therapeutic agent that suppresses the immune system, inhibiting lymphocyte functions, especially T and NK cells; IDs are used to treat IBD–ulcerative colitis, Crohn's disease Examples Azathioprine, mercaptopurine Adverse effects BM suppression, pancreatitis; ↑ lymphoma; cyclosporine Adverse effects Renal dysfunction; MTX Adverse effects BM suppression, liver toxicity
References in periodicals archive ?
Lentzsch, "The application and biology of immunomodulatory drugs (IMiDs) in cancer," Pharmacology & Therapeutics, vol.
Handa, "Cereblon and its downstream substrates as molecular targets of immunomodulatory drugs," International Journal of Hematology, vol.
When immunomodulatory drugs were evaluated for TSEP abnormality no significant difference was determined during the 2-year follow-up (Figure 9).
Inactive patients recruited into this study were receiving only salicylate or tapering budesonide without any immunomodulatory drug or antiTNF drug.
Topical immunomodulatory drugs and jewelweed are no help
In addition to its ProteoFlow screening capabilities, LigoCyte has immunomodulatory drug discovery and development activities in support of its own pipeline of therapeutic candidates.
Lenalidomide (Revlimid, Celgene, Switzerland), an analogue of thalidomide, is a kind of the immunomodulatory drug with potent anti-angiogenic and anti-inflammatory properties.
The Oncologic Drugs Advisory Committee (ODAC) voted 11 to 0 with 1 abstention that carfilzomib's risk-benefit profile is favorable for patients with relapsed and refractory multiple myeloma, who have received at least two prior lines of therapy that included a proteasome inhibitor and an immunomodulatory drug (IMiD)--the indication under review.
Merrimack Pharmaceuticals, Inc., Cambridge, Mass., has completed enrollment for a Phase IIa pilot study in patients with rheumatoid arthritis with its immunomodulatory drug candidate, MM-093, a recombinant version of human alpha-fetoprotein (AFP).
In addition to its ProteoFlow(R) screening capabilities, the company has immunomodulatory drug discovery and development activities in support of its own pipeline of therapeutic candidates.
Lenalidomide is a novel immunomodulatory drug related to thalidomide, which also has been used effectively in the treatment of multiple myeloma.