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The state in which the immune system does not react to the body's own antigens. It is caused by the destruction of lymphocytes that express receptors to autoantigens as they develop. Failure of these mechanisms may result in autoimmune disease.
See also: tolerance
immunological tolerancethe failure to respond to a potential antigen.
the ability to endure without effect or injury.
1. decreased susceptibility to the effects of a drug due to its continued administration.
2. the maximum permissible level of a drug in or on animal feed or food at any particular time relative to slaughter.
in immunology, that induced by the intravenous administration of high doses of aqueous proteins.
specific nonreactivity of the immune system to a particular antigen, which is capable under other conditions of inducing an immune response. There is, under normal circumstances, tolerance to self-antigens; identical (monozygotic) twins and dizygotic cattle or sheep twins where there has been placental fusion and exchange of bone marrow stem cells are also tolerant of each other's tissues. Allophenic mice, that is mice produced by fusion of blastocysts from different mice are also tolerant of both 'parents'. The administration of antigens either at high or low dose and infection with certain viruses during critical early stages of immunological development may also induce tolerance.
the concentration of a drug or chemical permitted by law to be present in human food.
the numerical limits within which a previously identified proportion of values of a variable, or observations in a population, can be expected to occur.
that induced by repeated administration of low doses of the antigen.
that induced by oral administration of the antigen.
the non-reactivity of the immune system to self-antigens.
see tolerance test.
when no detectable amount of a chemical substance is permitted in human food.