immunological tolerance


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Related to immunological tolerance: hypersensitivity, Acquired immunological tolerance

immunological tolerance

The state in which the immune system does not react to the body's own antigens. It is caused by the destruction of lymphocytes that express receptors to autoantigens as they develop. Failure of these mechanisms may result in autoimmune disease.
See also: tolerance

immunological tolerance

the failure to respond to a potential antigen.
References in periodicals archive ?
"The primary consideration will be determining whether immunological tolerance can be temporarily relaxed without leading to detrimental autoimmune manifestations and as a means to possibly elicit HIV-1 bnAbs with vaccination," he concluded.
This suggests that B7-H1 is important to maternal immunological tolerance of the fetal placenta.
If vertical transmission does occur, then the establishment of immunological tolerance to ABV must be considered.
In other cases, the tumoral progression coincides with the induction of specific immunological tolerance even during early stages of carcinogenesis.
Cholera toxin B subunit : an efficient transmucosal carrier-delivery system for induction of peripheral immunological tolerance. Proc Natl Acad Sci USA 1994; 91 : 10795-9.
380: Immunological Tolerance: Methods and Protocols
The drug's proposed mechanism of action is the induction or restoration of immunological tolerance with respect to ongoing immune attack as a result of high doses of peptide periodically delivered intravenously.
Immunological tolerance (innate or acquired) is briefly introduced as "the process by which the immune system does not attack an antigen." In two expert commentaries and eight contributed chapters, international scientists examine how advances in understanding regulatory T-cells and the use of transgenic plants and other recombinant technology methods are treating such challenges as inducing immune tolerance in patients with hemophilia, kidney transplants, and thymus gland defect-related intolerance problems in Type I diabetes.
AIRE is also expressed in peripheral dendritic cells and is thought to be involved in the maintenance of peripheral immunological tolerance. (4) Recently, (5) it has been shown that AIRE-deficient patients show reduced regulatory T-cell (TREG) activity.
Among those institutions is the JDRF/Beverly Berry Center for Immunological Tolerance at Harvard Medical School, named for the spouse of Fresh Market owner's Ray Berry.