immunologic unresponsiveness
immunologic unresponsiveness
(im″yŭ-nŏ-loj′ik ŭn″rē-spon′siv-nĕs)Tolerance to antigens that normally stimulate antibody production or cellular immunity.
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It is not uncommon for immune responses to dietary proteins to be viewed as having two possible outcomes: priming for allergic sensitization, or the development of tolerance resulting in immunologic unresponsiveness. On this basis, food allergy has been characterized as reflecting a breakdown in tolerance (Strobel 1997).
It is therefore inappropriate to regard oral tolerance as immunologic unresponsiveness; the more accurate descriptors would be hyporesponsiveness, or possibly partial responsiveness.
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