The immunoglobulin domains are represented as blue ovals for receptors and red ovals for ligands.
The extracellular region of TIM-3 consists of a mucin domain and an immunoglobulin domain to which the known ligands of TIM-3 bond, that is, galectin-9 (Gal-9) and phosphatidylserine (Ps) [48, 49].
For example, several contigs (e.g., Paramphinome jeffreysii 1 and Hemithris psittacea 2) included immunoglobulin domains
According to the first article, Titin, the largest protein in the human body, acts like a spring that stretches the muscle cell or slackens them and its spring region has certain protein units, the so-called immunoglobulin domains, which are strung like pearls on a string.
Under stress conditions, for example in acute heart failure, the spring region is excessively stretched and the immunoglobulin domains unfold.
Schulten, "Unfolding of titin immunoglobulin domains by steered molecular dynamics simulation," Biophysical Journal, vol.
Granzier, "Single molecule force spectroscopy on titin implicates immunoglobulin domain stability as a cardiac disease mechanism," The Journal of Biological Chemistry, vol.
"Different combinations of immunoglobulin domains
, which are coded by spliced exons, are used to produce a broad range of receptors.