immunodeficiency disorders

immunodeficiency disorders

Any one of a number of congenital or acquired conditions in which the body's immunological system of defence against infection, foreign material and some forms of cancer, is defective. Immunodeficiency may be of genetic origin, may be IATROGENIC or may be caused by infection with the human immunodeficiency virus (HIV) that has led to the development of AIDS. See also GENETIC IMMUNODEFICIENCY DISORDERS.
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The zoster vaccine is currently indicated in patients aged 60 years and older, but since it is a live attenuated vaccine, it is contraindicated in many patients who could benefit most from it, including those with primary immunodeficiency disorders, those with a hematologic malignancy, those who have had a hematopoietic stem cell transplant within the two years, pregnant patients, and patients taking high-dose steroids or anti-tumor necrosis factor biologics.
Some patients with B cell immunodeficiency could not be followed, so this study may not be an accurate reflection of all patients with B cell immunodeficiency disorders.
There are more than 300 primary immunodeficiency disorders, in which part of the body's immune system is missing or does not function properly.
The zoster vaccine (Zostavax, Merck) is currently indicated in patients aged 60 years and older, but since it is a live attenuated vaccine, it is contraindicated in many patients who could most benefit from it, including those with primary immunodeficiency disorders, those with a hematologic malignancy, those who have had a hematopoietic stem cell transplant within the last 2 years, pregnant patients, and patients taking high-dose steroids or anti-tumor necrosis factor biologies.
Broder spent his entire career in translational medicine, and his laboratory interests have included antiretroviral therapy, the relationship between immunodeficiency disorders and cancer, the human genome, and the proteomics of cancer cells.
Mycobacterial, fungal and other opportunistic infections force the clinician to rule out a large list of conditions associated with secondary immunodeficiency as infectious agents (HIV, Herpesvirus, HTLV), drugs (steroids, immunosuppressants, biologics, chemotherapy), metabolic diseases (diabetes, renal failure, cirrhosis), malignancies (leukemia, lymphomas and solid tumors) and environmental conditions (radiation, heavy metals) (2) but even adult patients can have late onset primary genetic immunodeficiency disorders as chronic granulomatous disease, X-linked agammaglobulinemia, interleukin-12 receptor deficiency or interferongamma (IFN-?
Thus epidermodysplasia verruciformis and other genetic or immunodeficiency disorders are described as a subset of generalized verrucosis (1, 2).
According to the report, UCB stem cells prove to be an effective treatment option for more than 80 diseases, such as cancer, immunodeficiency disorders, and blood disorders.
These include taking necessary vaccinations against a number of ailments like meningitis and seasonal flu - the latter applying, in particular, to those with heart disease, kidney failure, respiratory or nerve ailments, diabetes, congenital and acquired immunodeficiency disorders and metabolic diseases, along with pregnant women and obese children and those under five.
PV also has been described in different immunological abnormalities such as leukemia, lymphoma, malnutrition, HIV infection, and primary immunodeficiency disorders.
Immunologists, geneticists, pediatricians, and other medical specialists trace the history of knowledge about primary immunodeficiency disorders during the 60 years since they were first described.
They are also used in combating viral infections in people who have been suffering from immunodeficiency disorders.

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