To date, rare studies have been focusing on the correlation between CTCs and the distribution of
immunocytes in peripheral blood.
The regulatory genes that control hematopoiesis and immune reactions can be broadly divided between those that are specific to
immunocyte systems and those that are shared by other biological processes.
PPAR-[gamma], being highly expressed in
immunocytes, such as monocytes, macrophages, and lymphocytes [45], holds a pivotal role in adjusting inflammatory responses by regulating the activity of TNF-[alpha] in neuroprotective events [49, 50].
While manipulating the B cells and their families with the use of B-cell depleting therapy (BDT) appears very promising in the treatment of SLE and it is argued that B cells are relatively more important in the pathogenesis of SLE than other
immunocytes, the discrepantly prolonged beneficial effects of BDT against the much shorter half-life of rituximab invariably explain the potential importance of the participation of T cells in the pathogenic process of SLE [58, 59].
The IAP can dephosphorylate bacterial LPS which leads to LPS detoxification, thus preventing downstream activation of
immunocytes and the subsequent inflammatory responses.
A study showed that the volume of lesions in rat EM models was reduced from (331.40 [+ or -] 158.12) mm3 to (50.32 [+ or -] 33.28) mm3 after treatment with GZFLC for 4 weeks and the percentage of some
immunocytes was significantly increased including CD+3, CD+4, CD+4/CD+8, and NK cells in rat EM models, indicating that GZFLC plays an important role in suppressing endometriotic implants by regulating the immune function [105,106].
Decidua is a fetomaternal interface containing multiple
immunocytes, such as lymphocytes and macrophages, which play a central role in embryo embedding, placenta growth, and delivery [11].
In the pathogenesis of diabetes mellitus, proinflammatory cytokines such as tumor necrosis factor-[alpha] (TNF-[alpha]) and interleukin-6 (IL-6) could be produced by
immunocytes (like macrophages) and adipocytes [12-14].
Fausa, "J-Chain expression is more prominent in immunoglobulin A2 than in immunolgobulin A1 colonic
immunocytes and is decreased in both subclasses associated with inflammatory bowel disease," Gastroenterology, vol.
Gray cells, regarded as the
immunocytes of the sponge [10], bear the highly N-glycosylated CD44 surface antigen (T.
Turka, "Keratinocytes: key
immunocytes of the integument," American Journal of Pathology, vol.
Similar to other inflammatory and autoimmune conditions, the pathogenic processes that contributed to SLE involve complex interactions between
immunocytes and nonimmunocytes such as endothelial and epithelial cells through a number of receptor-ligand systems [2].