EDC (1-[3-Dimethylaminopropyl]--3-ethylcarbo-diimide hydrochloride) is a water-soluble carbodiimide which is used to activate the carboxyl group in amide reactions and cross-link proteins and nucleic acids for preparing immunoconjugates
In 1999, Hu and colleagues generated immunoconjugates
Of inactivated FVII and the Fc effector domain of human IgG1 (40).
Targeted endothelial delivery of nanosized catalase immunoconjugates
protects lung grafts donated after cardiac death," Transplantation, vol.
Cytotoxic properties of immunoconjugates
containing melittin-like peptide 101 against prostate cancer: in vitro and in vivo studies.
Their topics include the humanization of antibodies, affinity maturation approaches for antibody lead optimization, antibody expression from bacteria to transgenic animals, the design and application of immunoconjugates
for cancer therapy, and dual-targeting bispecific antibodies as new therapeutic modalities for cancer.
2007) Technology insight: Cytotoxic drug immunoconjugates
for cancer therapy.
Vaccination of mice with meth immunoconjugates
showed high antibody titers and high affinity for three particularly promising formulations (Moreno et al.
Effect of seven new vasoactive immunoconjugates
on the enhancement of tumor uptake of 99 mTc- labeled monoclonal antibody uptake in tumors.
Use of elevated temperature and optimized pH to achieve high specific activity and high chelate stability in radiolabeled immunoconjugates
Targeted therapy of cancer: New prospects for antibodies and immunoconjugates
Appropriate testing with different dilutions of the antigens, sera, and immunoconjugates
The new immunoconjugates
can be used in tumor therapy.