immunoconjugates

immunoconjugates

monoclonal antibodies which are target-specific carriers for specific compounds such as plant or bacterial toxins, radionuclides, photoactive agents and chemotherapeutic drugs.
References in periodicals archive ?
EDC (1-[3-Dimethylaminopropyl]--3-ethylcarbo-diimide hydrochloride) is a water-soluble carbodiimide which is used to activate the carboxyl group in amide reactions and cross-link proteins and nucleic acids for preparing immunoconjugates.
In 1999, Hu and colleagues generated immunoconjugates Of inactivated FVII and the Fc effector domain of human IgG1 (40).
Targeted endothelial delivery of nanosized catalase immunoconjugates protects lung grafts donated after cardiac death," Transplantation, vol.
Cytotoxic properties of immunoconjugates containing melittin-like peptide 101 against prostate cancer: in vitro and in vivo studies.
Their topics include the humanization of antibodies, affinity maturation approaches for antibody lead optimization, antibody expression from bacteria to transgenic animals, the design and application of immunoconjugates for cancer therapy, and dual-targeting bispecific antibodies as new therapeutic modalities for cancer.
2007) Technology insight: Cytotoxic drug immunoconjugates for cancer therapy.
Vaccination of mice with meth immunoconjugates showed high antibody titers and high affinity for three particularly promising formulations (Moreno et al.
Effect of seven new vasoactive immunoconjugates on the enhancement of tumor uptake of 99 mTc- labeled monoclonal antibody uptake in tumors.
Use of elevated temperature and optimized pH to achieve high specific activity and high chelate stability in radiolabeled immunoconjugates," Bioconjug.
Targeted therapy of cancer: New prospects for antibodies and immunoconjugates.
Appropriate testing with different dilutions of the antigens, sera, and immunoconjugates was conducted.
The new immunoconjugates can be used in tumor therapy.