The HCV recombinant immunoblast
assay (RIBA) can be used as a confirmatory test; however it is no longer regularly used in clinical practice.
In some cases, large transformed lymphocytes with immunoblast
morphology are markedly increased, in a background of karyorrhectic debris and scattered tingible body macrophages, which gives a histologic picture resembling high-grade lymphoma (Figure 2, B).
Numerous capillaries and cells, especially lymphocytes, admix with some plasma cells, and in rare cases, immunoblasts
ill the interfollicular areas.
The interfollicular area contains primarily histiocytes, plasma cells, and a few immunoblasts
with only a very few lymphocytes.
27) A dense infiltration of immunoblasts
, plasma cells including Russel bodies and mature lymphocytes and a pronounced fibrovascular framework are also present.
b) immunoblastic lymphomas (IBL) that, by convention, must contain at least 90% immunoblasts
(which have single, central, prominent nucleoli); and (c) CD30+ LBCL with anaplastic features (or histology).
The cellular areas were made up of atypical histiocytes with elongated, twisted nuclei and scant cytoplasm; immunoblasts
(transformed lymphocytes) with vesicular chromatin, large round nuclei, and prominent nucleoli; and lymphocytes (figure 2, C).
A population of cells consisting of histiocytes, immunoblasts
(predominantly of T-cell origin), and reactive lymphocytes was found within and around the necrotic area, with interspersed apoptotic bodies.
Primary cutaneous large B-cell lymphomas (leg type) (PCBLS) are diffuse large cell B-cell lymphomas with predominance or confluent sheets of centroblasts and immunoblasts
It does not provide informatio n of cell activation or signaling pathway receptors, frequency of T subsets such as the Th1 or Th2, stem or blast cells, or B-lymphocytes such as immunoblasts
or plasma cells, nor nonlymphoid elements.
Histologic analysis of affected lymph nodes generally reveals patchy necrosis, primarily in the paracortical area, and numerous adjacent crescentic histiocytes, lymphocytes, macrophages, and immunoblasts
(predominantly T cell) (figure 2).
2,3) Interestingly, it was noted that patients with a diffuse, monotonous infiltrate of centroblasts and/or immunoblasts
had a worse prognosis.