immunoadjuvant


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immunoadjuvant

 [im″u-no-aj´ah-vent, im″u-no-ad-joo´vent]
a nonspecific stimulator of the immune response, such as bcg vaccine or Freund's complete and incomplete adjuvants.

ad·ju·vant

(ad'jū-vănt),
1. A substance added to a drug product formulation that affects the action of the active ingredient in a predictable way.
2. immunology a vehicle used to enhance antigenicity; for example, a suspension of minerals (alum, aluminum hydroxide, or phosphate) on which antigen is adsorbed; or water-in-oil emulsion in which antigen solution is emulsified in mineral oil (Freund incomplete adjuvant), sometimes with the inclusion of killed mycobacteria (Freund complete adjuvant) to enhance antigenicity further (inhibits degradation of antigen and/or causes influx of macrophages).
3. Additional therapy given to enhance or extend primary therapy's effect, as in chemotherapy's addition to a surgical regimen.
4. A treatment added to a curative treatment to prevent recurrence of clinical cancer from microscopic residual disease.
[L. ad-juvo, pres. p. -juvans, to give aid to]
References in periodicals archive ?
Thus, we suggest that the nontoxic part of KML-B can be a potent immunoadjuvant for vaccination.
Kim et al., "Immunoadjuvant activity of Korean mistletoe lectin B-chain," Korean Journal of Pharmacognosy, vol.
TLR ligands are promising immunoadjuvants for immunotherapy since they stimulate many kinds of immune cells and initiate activation of antigen presentation by APCs [6].
Gregoriadis, "Liposomes as immunoadjuvants and vaccine carriers: antigen entrapment," ImmunoMethods, vol.
Greiner, "Chitosan solution enhances the immunoadjuvant properties of GM-CSF," Vaccine, vol.
During the last decades, much progress has been made on the development of immunoadjuvants. Several novel adjuvants are licensed for human use in different countries, including aluminum salts, squalene-oil-water emulsion (MF-59), monophosphoryl lipid (MPL) A and virosomes [19, 20].
Study on the immune enhancement of different immunoadjuvants used in the pentavalent vaccine for turbots.
The use of immunoadjuvants specifically designed to boost adultlike immunity, may be required (Leenstra et al.
Lacaille-Dubois MA (1999) Saponins as immunoadjuvants and immunostimulants in Immunomodulatory Agens from Plants, (Wagner et.