immunoadjuvant


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immunoadjuvant

 [im″u-no-aj´ah-vent, im″u-no-ad-joo´vent]
a nonspecific stimulator of the immune response, such as bcg vaccine or Freund's complete and incomplete adjuvants.

ad·ju·vant

(ad'jū-vănt),
1. A substance added to a drug product formulation that affects the action of the active ingredient in a predictable way.
2. immunology a vehicle used to enhance antigenicity; for example, a suspension of minerals (alum, aluminum hydroxide, or phosphate) on which antigen is adsorbed; or water-in-oil emulsion in which antigen solution is emulsified in mineral oil (Freund incomplete adjuvant), sometimes with the inclusion of killed mycobacteria (Freund complete adjuvant) to enhance antigenicity further (inhibits degradation of antigen and/or causes influx of macrophages).
3. Additional therapy given to enhance or extend primary therapy's effect, as in chemotherapy's addition to a surgical regimen.
4. A treatment added to a curative treatment to prevent recurrence of clinical cancer from microscopic residual disease.
[L. ad-juvo, pres. p. -juvans, to give aid to]

immunoadjuvant

/im·mu·no·ad·ju·vant/ (im″u-no-aj´dbobr-vant) (-ad-joo´vant) a nonspecific stimulator of the immune response, e.g., BCG vaccine or Freund's complete and incomplete adjuvants.

immunoadjuvant

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References in periodicals archive ?
Inovio has already demonstrated superior advantages in the magnitude and breadth of killer T cell immune responses induced in non-human primates by one of its optimized SynCon[TM] DNA vaccines delivered using its proprietary electroporation technology, without the use of an immunoadjuvant.
The agreement is representative of the growing interest in DC-Cholesterol for use in a variety of contexts, including its use as an immunoadjuvant and for delivery of tumor suppressor genes," commented Martin H.
Hunter's TiterMax(R), an important immunoadjuvant for use by the basic research community, is currently on the market; and feed additives intended to enhance growth in food animals are under development through Vetlife(TM), Inc.
The solution of the immunoadjuvants admixed with indocyanine green (ICG), a light-absorbing dye, was injected directly into the tumors, followed by noninvasive irradiation of an 805 nm laser.
The use of immunoadjuvants specifically designed to boost adultlike immunity, may be required (Leenstra et al.
Quest is a publicly traded, Alberta-based biotechnology company committed to the development and commercialization of oncology product candidates for the treatment of cancer by combining immunotherapeutic antibodies with chemotherapy, photodynamic therapy or immunoadjuvants.