immunoadjuvant


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immunoadjuvant

 [im″u-no-aj´ah-vent, im″u-no-ad-joo´vent]
a nonspecific stimulator of the immune response, such as bcg vaccine or Freund's complete and incomplete adjuvants.

ad·ju·vant

(ad'jū-vănt),
1. A substance added to a drug product formulation that affects the action of the active ingredient in a predictable way.
2. immunology a vehicle used to enhance antigenicity; for example, a suspension of minerals (alum, aluminum hydroxide, or phosphate) on which antigen is adsorbed; or water-in-oil emulsion in which antigen solution is emulsified in mineral oil (Freund incomplete adjuvant), sometimes with the inclusion of killed mycobacteria (Freund complete adjuvant) to enhance antigenicity further (inhibits degradation of antigen and/or causes influx of macrophages).
3. Additional therapy given to enhance or extend primary therapy's effect, as in chemotherapy's addition to a surgical regimen.
4. A treatment added to a curative treatment to prevent recurrence of clinical cancer from microscopic residual disease.
[L. ad-juvo, pres. p. -juvans, to give aid to]

immunoadjuvant

/im·mu·no·ad·ju·vant/ (im″u-no-aj´dbobr-vant) (-ad-joo´vant) a nonspecific stimulator of the immune response, e.g., BCG vaccine or Freund's complete and incomplete adjuvants.

immunoadjuvant

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References in periodicals archive ?
In contrast, a gene immunoadjuvant is a DNA plasmid encoded with the genetic blueprint of an important, naturally occurring immune molecule such as IL-28B.
The solution of the immunoadjuvants admixed with indocyanine green (ICG), a light-absorbing dye, was injected directly into the tumors, followed by noninvasive irradiation of an 805 nm laser.
The use of immunoadjuvants specifically designed to boost adultlike immunity, may be required (Leenstra et al.
Most recently he was the founder Chief Scientific Officer of Parallel Solutions from 2001 until 2005, where he developed biodegradable polymers for protein delivery and discovered a new class of potent vaccine immunoadjuvants.