immunoadhesin

immunoadhesin

(ĭm″ū-nō-ăd-hē′sĭn) [L. immunis, safe, + adhaerēre, to stick to]
A genetically engineered, antibody-like protein that fuses the Fc region of an immunoglobulin and the ligand-binding region of a receptor or adhesion molecule. Immunoadhesins can be used to direct the immune-responsive effect of cytokines to tumor cells and to stimulate the destruction of such cells.
References in periodicals archive ?
The transmembrane activator and calcium-modulating and cyclophilin ligand interactor immunoadhesin adenoviral vectors failed to decrease production of anti-ganglioside antibodies in mice sensitized with C.
P55 TNF receptor immunoadhesin prevents T-cell-mediated intestinal injury by inhibiting matrix metalloproteinase production.
Successfully defended Genentech's European patent relating to immunoadhesin therapeutics against challenges filed by Biogen and Genetics institute.
Genentech scientist Avi Ashkenazi told the sepsis meeting that in cell culture tests, his company's so-called immunoadhesin sopped up five times more TNF than did an anti-TNF antibody alone.
Like Genetech's immunoadhesin, the Immunex molecule allowed a majority of mice to survive a lethal dose of endotoxin given three hours previously.
Signed a license agreement with Immunex Corporation that grants rights under Genentech's immunoadhesin patent portfolio to Immunex for its product Enbrel.
NYSE:GNE) and Immunex Corporation (Nasdaq:IMNX) announced today that the two companies have signed a license agreement that grants rights under Genentech's immunoadhesin patent portfolio to Immunex for its product ENBREL(R).
ENBREL is a soluble receptor fusion protein, and is the first product utilizing immunoadhesin technology to be approved by the U.
After it was proven to work against SIV in the laboratory, DNA representing SIV-specific immunoadhesins was engineered into a carrier virus designed to deliver the DNA to monkeys.
In the second part of the study, the team injected AAV carriers into the muscles of monkeys, where the imported DNA produced immunoadhesins that entered the blood circulation.
The antibody-like molecules, dubbed immunoadhesins, not only sop up criculating AIDs viruses but also contain protein fragments with the potential to trigger an immune response against the virus, HIV.
Significantly, they add, animal experiments indicate immunoadhesins will remain in the human body nearly 200 times longer than run-of-the-mill CD4, which can disappear from circulation within a few hours.