Ashkenazi, "Inhibition of interferon-gamma by an interferon-gamma receptor immunoadhesin
," Immunology, vol.
created an immunoadhesin form of CD4, named eCD4Ig, which is comprised of CD4-Ig and CCR5mim1 fused to the human IgG1 Fc domain .
In recent years, many immunoadhesins that share functions in common with eCD4-Ig have been created.
(179) In splenocyte culture, however, anti-ganglioside antibodies were produced in the presence of a soluble transmembrane activator and calcium-modulating and cyclophilin ligand interactor immunoadhesin
, a receptor for B-cell-activating factor belonging to the tumor necrosis factor family.
P55 TNF receptor immunoadhesin
prevents T-cell-mediated intestinal injury by inhibiting matrix metalloproteinase production.
-- Successfully defended Genentech's European patent relating to immunoadhesin
therapeutics against challenges filed by Biogen and Genetics institute.
Genentech scientist Avi Ashkenazi told the sepsis meeting that in cell culture tests, his company's so-called immunoadhesin sopped up five times more TNF than did an anti-TNF antibody alone.
Like Genetech's immunoadhesin, the Immunex molecule allowed a majority of mice to survive a lethal dose of endotoxin given three hours previously.
However, the approach used in the current study was divided into two phases-in the first phase, researchers created antibody-like proteins (called immunoadhesins) that were specifically designed to bind to SIV and block it from infecting cells.
After it was proven to work against SIV in the laboratory, DNA representing SIV-specific immunoadhesins was engineered into a carrier virus designed to deliver the DNA to monkeys.
The antibody-like molecules, dubbed immunoadhesins, not only sop up criculating AIDs viruses but also contain protein fragments with the potential to trigger an immune response against the virus, HIV.
The reserachers tested immunoadhesins' ability to protect cultured cells exposed to HIV.