The transmembrane activator and calcium-modulating and cyclophilin ligand interactor immunoadhesin
adenoviral vectors failed to decrease production of anti-ganglioside antibodies in mice sensitized with C.
P55 TNF receptor immunoadhesin
prevents T-cell-mediated intestinal injury by inhibiting matrix metalloproteinase production.
Successfully defended Genentech's European patent relating to immunoadhesin
therapeutics against challenges filed by Biogen and Genetics institute.
Genentech scientist Avi Ashkenazi told the sepsis meeting that in cell culture tests, his company's so-called immunoadhesin sopped up five times more TNF than did an anti-TNF antibody alone.
Like Genetech's immunoadhesin, the Immunex molecule allowed a majority of mice to survive a lethal dose of endotoxin given three hours previously.
After it was proven to work against SIV in the laboratory, DNA representing SIV-specific immunoadhesins was engineered into a carrier virus designed to deliver the DNA to monkeys.
In the second part of the study, the team injected AAV carriers into the muscles of monkeys, where the imported DNA produced immunoadhesins that entered the blood circulation.
The antibody-like molecules, dubbed immunoadhesins, not only sop up criculating AIDs viruses but also contain protein fragments with the potential to trigger an immune response against the virus, HIV.
Significantly, they add, animal experiments indicate immunoadhesins will remain in the human body nearly 200 times longer than run-of-the-mill CD4, which can disappear from circulation within a few hours.