In a single case report, abatacept produced both clinical improvement and normalization of laboratory parameters in a patient who had failed to respond to methotrexate, TNF inhibitors, steroid, immunoabsorption
, plasmapheresis, and IL- inhibition.
Torre-Amione noted that although nonspecific immunoregulatory therapies such as plasmapheresis and immunoabsorption are unfamiliar to cardiologists, these therapies are scoring successes in other fields, particularly for autoimmune and neuroinflammatory diseases.
In another study by the same group, patients with advanced heart failure who had antibodies that fostered reduced calcium movement and depressed myocyte contractility responded to removal of these antibodies through immunoabsorption with an increase in ejection fraction; patients without these antibodies didn't respond.
Lower concentrations of an analyte maybe achieved by removing an analyte, for example by immunoabsorption
on a solid phase.
This is also supported by the observation that the immunoabsorption
of IgA-class autoantibodies against TGc by guinea pig TGc cannot completely abrogate antiendomysium activity (28), although these experiments should be repeated using calcium-activated human TGc because not all patients' antibodies may cross-react with the guinea pig antigen.
These MAbs were also used for immunoabsorption
Pure CA I and CA II IgGs were prepared by an immunoabsorption
method in which purified human CA I and CA II antigens (Sigma Aldrich) were attached to N-hydroxysuccinimide (NHS)-activated columns (HiTrap NHS-activated column; no.
22) have demonstrated that although tTG immunoabsorption
is enough to abrogate anti-tTG EIA reactivity, it failed to completely abolish EMA binding activity.
Neither combination nor sequential treatment with IVIg and plasma exchange is supported by published evidence, nor is the use of cerebral spinal fluid filtration or immunoabsorption
Before IgM and IgA were determined by IFA, antibodies of class IgG were removed from the patient's serum by antihuman IgG by using two immunoabsorption
kits: EUROSORB (EUROIMMUN) for commercial IFA and GULLSORB (Meridian Bioscience Inc.
109] in 1988 performed blocking and immunoabsorption
studies on the serum of patients with TSH concentrations abnormally increased because of HAMA.
As a result, they often are more difficult to remove or neutralize by immunoabsorption
techniques than specific HAAAs (6-8,11, 18).