Aymeric et al., "Cancer-induced immunosuppression: IL-18-elicited immunoablative
NK cells," Cancer Research, vol.
Following immunoablative therapy, ACPA-IgG of low avidity developed again which suggested a newly generated autoimmune response .
Verpoortet al., "Differential responsiveness to immunoablative therapy in refractory rheumatoid arthritis is associated with level and avidity of anti-cyclic citrullinated protein autoantibodies: a case study," Arthritis Research & Therapy, vol.
After receiving an autologous stem cell transplant (SCT), she experienced a relapse of disease and was enrolled in an experimental protocol of immunoablative
chemotherapy, followed by hematopoietic SCT at the National Institutes of Health Clinical Center in Bethesda, Maryland (www.ClinicalTrials.gov identifier NCT00520130).
The authors concluded that this immunoablative
regimen of cyclophosphamide for patients with aggressive MS was safe, worthy of further study and may be an alternative to bone marrow transplantation.
Evaluating the role of immunoablative
high-dose cyclophosphamide therapy in pemphigus vulgaris.
A key to the success of this program is that patients receive a conditioning regimen that is immunoablative
but not myeloablative.
The use of G-CSF did not induce inflammatory activity in the central nervous system; CNS antibody production decreased after immunoablative