Immune Thrombocytopenia (ITP) is an acquired autoimmune, haematological disorder characterized by isolated thrombocytopenia (peripheral blood platelet count <100x109/ l) in the absence of other causative systemic disorders.1,2 The pathogenesis of ITP remains incompletely understood.
Platelet size distinguishes between inherited macrothrombocytopenias and
immune thrombocytopenia. J Thromb Haemost.
Nakasho, "Autoimmune hepatitis concomitant with hypergammaglobulinemic purpura,
immune thrombocytopenia, and Sjogren's syndrome," Internal Medicine, vol.
Combining therapies (corticosteroids and IVIg) is appropriate for the emergency treatment of primary
immune thrombocytopenia patients with uncontrolled bleeding and severe thrombocytopenia especially when an urgent increase in platelet count is required, e.g., before surgical procedures or with active central nervous system (CNS), gastrointestinal (GI), or genitourinary bleeding [13].
Espinosa, "Effectiveness of thrombopoietin-receptor agonists in the treatment of refractory
immune thrombocytopenia associated to systemic lupus erythematosus," Journal of Rheumatology, vol.
Further information about this case is that
immune thrombocytopenia can be related to localized amyloidosis with a predisposing factor.
Semple, "Pathogenesis of
immune thrombocytopenia," Presse Medicale, vol.
Semple, "Pathogenesis and therapeutic mechanisms in
immune thrombocytopenia (ITP)," Journal of Clinical Medicine, vol.
Roganovic, "Celiac disease with Evans syndrome and isolated
immune thrombocytopenia in monozygotic twins: a rare association," Seminars in Hematology, vol.
Therefore, these indices are effective in distinguishing infective and
immune thrombocytopenia from other types and these findings are consistent with previous findings of Borkataky et al [15] where platelet indices [16] were found to be useful in the differential diagnosis of infective and
immune thrombocytopenia from other causes.
Immune thrombocytopenia (ITP) is an acquired immune-mediated disease characterized by isolated thrombocytopenia, and is characterized by increased platelet destruction that is mediated by autoantibodies.