immune surveillance


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im·mune sur·veil·lance

a theory that the immune system recognizes and destroys tumor cells that are constantly arising during the life of the individual.

immune surveillance

im·mune sur·veil·lance

(i-myūn' sŭr-vā'lăns)
A theory that the immune system destroys tumor cells, which are constantly arising during the life of the individual.
Synonym(s): immunologic surveillance.

immune surveillance

A body mechanism by which early cancers are detected as being foreign and are attacked and usually destroyed. Immune surveillance is a T cell-mediated process without which cancer would be much commoner. See also CTLA4-IG.

immune

1. being highly resistant to a disease because of the formation of humoral antibodies or the development of immunologically competent cells, or both, or as a result of some other mechanism, such as interferon activities in viral infections.
2. characterized by the development of antibodies or cellular immunity, or both, following exposure to antigen.
3. produced in response to antigen, such as immune serum globulin. The essential feature of antibody and cell-mediated immunity is that they are highly antigen specific.

immune adherence
the binding of antibody-antigen-complement complexes to complement receptors found on red blood cells.
immune complex
see antibody-antigen complex.
immune complex disease
disease induced by the deposition of or association with antigen-antibody-complement complexes in the microvasculature of tissues. Fixation of complement component C3 by the complexes initiates inflammation. See also serum sickness, hypersensitivity.
immune complex reaction
type III hypersensitivity (1).
immune deficiency disease
one in which animals have inadequate immune responses and so are more susceptible to infectious disease. The defect may be primary (inherited), or secondary (acquired) which usually develops after birth because of toxins or infectious agents. See also combined immune deficiency syndrome, hypogammaglobulinemia, agammaglobulinemia, inherited parakeratosis, chediak-higashi syndrome and canine granulocytopathy syndrome.
immune hemolysis
see immune-mediated hemolytic anemia (below).
immune interferon
immune modulator
immune reaction
immune response.
immune reaction fever
aseptic fever occurring in anaphylaxis, angioedema.
immune response
the specific response to substances interpreted by the body as not-self, the result being humoral and cellular immunity. The immune response depends on a functioning thymus and the conversion of stem cells to B and T lymphocytes. These B and T lymphocytes contribute to antibody production, cellular immunity and immunological memory. See also humoral immunity.
immune response (Ir) genes
see immune response genes.
immune surveillance
the detection by lymphocytes, especially T lymphocytes, of new antigens, particularly on tumor cells.
immune system
consists of the primary lymphoid organs (thymus and Bursa of Fabricius or its equivalent (bone marrow) in mammals) and secondary lymphoid organs (lymph nodes, spleen and other lymphoid tissue).
immune tolerance
see immunological tolerance.
References in periodicals archive ?
Immune surveillance of human cancer: if the cytotoxic T-lymphocytes play the music, does the tumoral system call the tune?
His development of disease may reflect a combination of low antitoxin titer at the time of infection and the bypassing of immune surveillance through direct access to alpha motor neurons at the site of infection.
Immune surveillance of unhealthy cells by natural killer cells.
The researcher said that their finding that immune surveillance by T cells enables early detection and elimination of these cancerous and pre-cancerous cells provides an answer to this puzzle, and proves that immune surveillance is essential to preventing the development of this blood cancer.
When blood flow is reduced, immune surveillance in those organs is also reduced and oxygen and nutrient delivery is depressed.
She noted that, at times, products might positively support immune surveillance but also inhibit migration in response to inflammatory mediators.
Perhaps because of a suppressed immune system and impaired immune surveillance, malignancies take a more aggressive clinical course in those infected with HIV.
The increased prevalence of autoimmune disease in women with endometriosis supports the theory that altered immune surveillance plays a role in the etiology of endometriosis.
First, the health benefits for the breast-fed infant are well documented and include decreased rates of diarrhea and of respiratory, ear, and urinary tract infections as well as increased immune surveillance (32).
In the case of cancer, immune surveillance fails to destroy cancer cells.
Since higher chain length acyl-carnitines have an inhibitory effect on NF-kB activation, these metabolites may also reflect changes in immune surveillance, and may help explain the profound chemotherapy resistance seen with this cancer.
Adenosine and TGFE- both drive immune suppression in the tumor microenvironment, which allows cancer cells to escape immune surveillance, making inhibition of these two pathways an attractive next-generation immuno-oncology approach.