immune serum

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Related to immune serum: immune serum globulin


 [se´rum] (pl. serums, se´ra) (L.)
the clear portion of any animal or plant fluid that remains after the solid elements have been separated out. The term usually refers to blood serum, the clear, straw-colored, liquid portion of the plasma that does not contain fibrinogen or blood cells, and remains fluid after clotting of blood. Blood serum from persons or animals whose bodies have built up antibodies is called antiserum or immune serum. Inoculation with such an antiserum provides temporary, or passive, immunity against the disease, and is used when a person has already been exposed to or has contracted the disease. Diseases in which passive immunization is sometimes used include diphtheria, tetanus, botulism, and gas gangrene.
antilymphocyte serum (ALS) antiserum derived from animals that have been immunized against human lymphocytes, a powerful nonspecific immunosuppressive agent that causes destruction of circulating lymphocytes.
antirabies serum antiserum obtained from the blood serum or plasma of animals immunized with rabies vaccine; used for postexposure prophylaxis against rabies if rabies immune globulin is unavailable.
blood grouping s's preparations containing particular antibodies against red cell antigens, used for blood typing. Those most commonly used are the anti-A and anti-B blood grouping serums used to determine ABO blood types and the anti-Rh blood grouping serums (anti-D, anti-C, anti-E, anti-c, and anti-e) used to determine Rh blood types.
serum glutamic-oxaloacetic transaminase (SGOT) see aspartate transaminase.
serum glutamic-pyruvic transaminase (SGPT) see alanine transaminase.
immune serum antiserum.
pooled serum the mixed serum from a number of individuals.
serum sickness a hypersensitivity reaction following the administration of foreign serum or other antigens; it is marked by urticarial rashes, edema, adenitis, joint pains, high fever, and prostration. Reactions to tetanus antitoxin derived from horse serum were especially common but are now rare owing to refinement of the antigenic components.
serum sickness syndrome a serum sickness–like hypersensitivity reaction occurring after the administration of certain drugs. It is marked clinically by low-grade fever, urticaria, facial edema, pain and swelling of the joints, and lymphadenopathy, and occasionally may be associated with neuritis of the brachial plexus, guillain-barré syndrome, periarteritis nodosa, and nephritis.
Miller-Keane Encyclopedia and Dictionary of Medicine, Nursing, and Allied Health, Seventh Edition. © 2003 by Saunders, an imprint of Elsevier, Inc. All rights reserved.


Polyclonal serum that contains demonstrable antibody or antibodies specific for one (monovalent or specific antiserum) or more (polyvalent antiserum) antigens; may be prepared from the blood of animals inoculated with an antigenic material or from the blood of animals and people who have been stimulated by natural contact with an antigen (as in those who recover from an attack of disease).
Synonym(s): immune serum
Farlex Partner Medical Dictionary © Farlex 2012


Serum that contains antibody or antibodies specific for one or more antigens; may be prepared from the blood of animals inoculated with an antigenic material or from the blood of animals and people who have been stimulated by natural contact with an antigen (as by an attack of disease).
Synonym(s): immune serum.
Medical Dictionary for the Health Professions and Nursing © Farlex 2012
References in periodicals archive ?
HI antibody titer of the immune serum was 1:1,280; PRN titer was 1:5,120.
Each of the three immunization products evaluated in this study (killed whole virus vaccine, live attenuated chimeric virus vaccine, and passive immunization with immune serum) protected hamsters from clinical encephalitis and death upon subsequent challenge with the virulent wild-type WNV strain NY385-99.
Hamsters inoculated with WNV immune serum (0.5 mL and 0.1 mL) appeared to be completely protected when challenged with the wild-type virus 24 hours after passive immunization (Table 6).
Importance of dose of neutralizing antibodies in treatment of Argentine haemorrhagic fever with immune serum. Lancet 1984;2:255-6.
In a second immunoblotting experiment, we were interested to know whether the whole immune serum contained antibodies against both peptides used to immunize the rabbit.
In a third immunoblotting experiment, the specificity of the immune serum was further tested by pre-incubation with the two [PpCa.sub.v][beta] peptides used to immunize the rabbit (Fig.
Rabbits of group A, B, C and D were inoculated with 1ml of 64, 128, 256 and 512 IHA units of hyper immune serum respectively through intravenous route.
a, 1ml of hyper immune serum was injected intravenously to each rabbit; b, Each rabbit was injected intramuscularly with 0.1ml suspension of PM LD5010-6.749; c, percentage recovery
Binding of DENV immune serum to Zika virus virions.
Immune serum was depleted with DENV-1 and DENV-2 antigens bound to polystyrene beads, and neutralization activity was measured against DENV-2 (A), DENV-4 (B), and Zika virus (C) for indicated serum.
Flagellin a antiserum in the immune serum showed significantly higher killing ability against homologous strain PAK (78.61%, P <0.01) in comparison with PAO1 strain (33.56%, Figure 3).
Also, the survival rate was not decreased compared to the control group when challenged by PAK (Figure 2(a)) and PAO1 (Figure 2(b)), since the killing ability of immune serum against P.