Immune reconstitution syndrome, including the occurrence of autoimmune disorders with variable time to onset, has been reported.
The role of the thymus in
immune reconstitution in aging, bone marrow transplantation, and HIV-1 infection.
When the transplant is performed without chemotherapy, most achieve only partial
immune reconstitution, continue to have significant chronic medical problems, and also require life-long treatment with monthly injections of supplemental immunoglobulin (antibodies).
The presentation described in-depth
immune reconstitution data from the completed Phase 1/2, multi-center clinical study of NiCord as a stand-alone graft after myeloablative therapy in patients with high-risk hematologic malignancies.
Evidence of
immune reconstitution was observed in patients treated with OTL-101.
(17) A lack of CD8+ T cells in HSCT patients is associated with CMV infection, whereas
immune reconstitution of CD8+ T cells is correlated with protection against CMV.
The most common appearances of CNS cryptococcal infection in patients with human immunodeficiency virus (HIV) are meningoencephalitis, cryptococcoma, dilated Virchow-Robin spaces, dirty cranial base and so on.[6],[7],[8],[9],[10],[11],[12],[13] However, leptomeningitis or meningoencephalitis is much more common in HIV patients with
immune reconstitution.[8],[9],[10],[12] The pathogenesis and imaging appearances of CNS cryptococcal infection largely depend on the patients' immunity.
The SCOT (Scleroderma: Cyclophosphamide or Transplantation) trial randomized 75 patients with severe scleroderma and substantial internal organ involvement to receive treatment with either cyclophosphamide or myeloablative radiation followed by
immune reconstitution with an autologous hematopoietic stem cell transplant.
Exceptions were maintained for patients not ready to start therapy and those at risk for
immune reconstitution syndrome.
Chylous ascites as a late complication of
immune reconstitution inflammatory syndrome (IRIS) in patients with HIV and colonic Mycobacterium avium complex (MAC) is an uncommon occurrence and has rarely been reported in the literature.
However PT/Cy results in delayed
immune reconstitution and higher rates of life threatening infections.
Staging disease with CD4 T cell counts also does not justify waiting any longer, (1,7) except for patients with some clinical AIDS conditions associated to the risk of severe
immune reconstitution syndrome, as when active tuberculosis or cryptococcosis are suspected.
