immune globulin


Also found in: Dictionary, Thesaurus, Acronyms, Encyclopedia, Wikipedia.

globulin

 [glob´u-lin]
any of numerous proteins that are insoluble in water or highly concentrated salt solutions but soluble in moderately concentrated salt solutions. All plasma proteins except albumin and prealbumin are globulins. The plasma globulins are separated into five fractions by serum protein electrophoresis (SPE). In order of decreasing electrophoretic mobility these fractions are the alpha1-, alpha2-, beta1-, and beta2-globulins, and the gamma globulins.

The globulins include carrier proteins, which transport specific substances; acute phase reactants, which are involved in the inflammatory process; coagulation factors; complement components; and immunoglobulins. Examples are transferrin, a beta1-globulin that transports iron, and alpha1-antitrypsin, an acute phase reactant that inhibits serum proteases. The gamma globulin fraction is almost entirely composed of immunoglobulins.
accelerator globulin factor V, one of the coagulation factors.
antihemophilic globulin (AHG) factor VIII, one of the coagulation factors.
antilymphocyte globulin (ALG) the gamma globulin fraction of antilymphocyte serum; used as an immunosuppressant in organ transplantation. The term is sometimes used interchangeably with antithymocyte globulin.
antithymocyte globulin (ATG) the gamma globulin fraction of antiserum derived from animals (such as rabbits) that have been immunized against human thymocytes; an immunosuppressive agent that causes specific destruction of T lymphocytes, used in treatment of allograft rejection. The term is sometimes used interchangeably with antilymphocyte globulin.
bacterial polysaccharide immune globulin (BPIG) a human immune globulin derived from the blood plasma of adult human donors immunized with Haemophilus influenzae type b, pneumococcal, and meningococcal polysaccharide vaccines; used for passive immunization of infants under 18 months of age.
cytomegalovirus immune globulin a purified immunoglobulin derived from pooled adult human plasma selected for high titers of antibody against cytomegalovirus; administered intravenously for treatment and prophylaxis of cytomegalovirus disease in transplant recipients.
gamma globulin
hepatitis B immune globulin (HBIG) a specific immune globulin derived from plasma of human donors with high titers of antibodies against hepatitis B surface antigen (HBsAg); used for postexposure prophylaxis following contact with HBsAg-positive materials, also administered to infants of HBsAg-positive mothers.
hyperimmune globulin any of various immune globulin preparations especially high in antibodies against certain specific diseases.
immune globulin
2. a concentrated preparation containing mostly gamma globulins, predominantly IgG, from a large pool of human donors; used for passive immunization against measles, hepatitis A, and varicella and for treatment of hypogammaglobulinemia or agammaglobulinemia in immunodeficient patients, administered intramuscularly. See also immune g. intravenous (human).
immune globulin intravenous (human) a preparation of immune globulin suitable for intravenous administration; used in the treatment of primary immunodeficiency disorders and idiopathic thrombocytopenic purpura, and as an adjunct in the treatment of Kawasaki disease and the prevention of infections associated with chronic lymphocytic leukemia, bone marrow transplantation, and pediatric human immunodeficiency virus infection.
immune human serum globulin immune globulin (def. 2).
immune serum globulin immune g. (def. 2).
pertussis immune globulin a specific immune globulin derived from the blood plasma of human donors immunized with pertussis vaccine; used for the prophylaxis and treatment of pertussis.
rabies immune globulin a specific immune globulin derived from plasma of human donors hyperimmunized with rabies vaccine; administered in conjunction with rabies vaccine in cases of bite or scratch exposure to known or suspected rabid animals.
respiratory syncytial virus immune globulin intravenous a preparation of immunoglobulin G from pooled adult human plasma selected for high titers of antibodies against respiratory syncytial virus; used for passive immunization of infants and young children.
Rh0(D) immune globulin a specific immune globulin derived from human blood plasma containing antibody to the erythrocyte factor Rh0(D); used to prevent Rh-sensitization of Rh-negative females and thus prevent erythroblastosis fetalis in subsequent pregnancies; administered within 72 hours after exposure to Rh-positive blood resulting from delivery of an Rh-positive child, abortion or miscarriage of an Rh-positive fetus, or transfusion of Rh-positive blood. It is also used as a platelet count stimulator in the treatment of idiopathic thrombocytopenic purpura.
serum g's all plasma proteins except albumin, which is not a globulin, and fibrinogen, which is not in the serum. The serum globulins are subdivided into alpha-, beta-, and gamma-globulins on the basis of their relative electrophoretic mobilities.
specific immune globulin a preparation of immune globulin derived from a donor pool preselected for high antibody titer against a specific antigen, such as hepatitis B immune globulin.
tetanus immune globulin a specific immune globulin derived from the blood plasma of human donors who have been immunized with tetanus toxoid; used in the prophylaxis and treatment of tetanus.
thyronine-binding globulin (TBG) (thyroxine-binding globulin) an acidic glycoprotein that is the main binding protein in the blood for thyroxine, and less firmly for triiodothyronine.
vaccinia immune globulin a specific immune globulin derived from the blood plasma of human donors who have been immunized with vaccinia virus smallpox vaccine; used as a passive immunizing agent.
varicella-zoster immune globulin (VZIG) a specific immune globulin derived from plasma of human donors with high titers of varicella-zoster antibodies; used for prevention or amelioration of varicella in immunocompromised patients exposed to the disease and in neonates whose mothers develop varicella in the perinatal period.

immune globulin

n.
Globulin from the blood of a person or animal immune to a certain disease, such as measles. Also called immune serum globulin.

Immune globulin

Serum containing antibodies against a specific infection.
References in periodicals archive ?
(45) Regarding the history of administration of Rh immune globulin to pregnant women with a weak D phenotype, the American College of Obstetricians and Gynecologists (ACOG) first addressed the subject in a 1981 practice bulletin.
The main modality of therapy, also known as disease modifying treatment for Guillain-Barre syndrome (GBS) includes plasma exchange (also called plasmaphoresis) and administration of intravenous immune globulin (IVIG).3 The other aspect of management is supportive care.
After exposure, vaccine trumps immune globulin in healthy patients
This left 740 patients in the vaccine group and 674 in the immune globulin group (the modified intention-to-treat analysis groups).
In addition, the mothers of children with autism were not more likely to have been exposed to antepartum Rh immune globulin containing thimerosal, and were not more likely to have an Rh-negative incompatible pregnancy These findings were also true for autism subtypes.
Costs included personnel time (combined total of 900 hours), related benefits, immune globulin, administrative support, and supplies.
For example, in a comparison of the activity of human MAbs with that of human immune globulin, 0.7 mg of a mixture of two MAbs had the same neutralizing activity as 100 mg-170 mg of tetanus immune globulin (90).
Because maternal antibodies appeared to protect infants from RSV infection during the first few months after birth, researchers began evaluating intravenous immune globulin (IVIG) as a means of preventing RSV illness.
Those planning to travel to areas where hepatitis A is widespread are advised to take immune globulin before leaving.
government has never awarded a 10-year contract for Vaccinia Immune Globulin Intravenous, and the last VIGIV contract was a 1-year $26M contract that was signed in February 2018, he points out, adding the contract prior to that was a 3-year $92M contract.
The complaint also alleged that, absent a remedy, the acquisition is likely to have harmed the United States market for hepatitis B immune globulin, or HBIG, a plasma-derived injectable medicine that provides hepatitis B antibodies for preventing hepatitis B infections.
An infant aged 10 days was identified within the first 6 days of exposure and offered postexposure prophylaxis with intramuscular (IM) immune globulin. A second infant was identified later and was outside of the window period for immune globulin.

Full browser ?