immune globulin


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Related to immune globulin: tetanus immune globulin, hepatitis B immune globulin, rabies immune globulin, Immune Globulin Intravenous

globulin

 [glob´u-lin]
any of numerous proteins that are insoluble in water or highly concentrated salt solutions but soluble in moderately concentrated salt solutions. All plasma proteins except albumin and prealbumin are globulins. The plasma globulins are separated into five fractions by serum protein electrophoresis (SPE). In order of decreasing electrophoretic mobility these fractions are the alpha1-, alpha2-, beta1-, and beta2-globulins, and the gamma globulins.

The globulins include carrier proteins, which transport specific substances; acute phase reactants, which are involved in the inflammatory process; coagulation factors; complement components; and immunoglobulins. Examples are transferrin, a beta1-globulin that transports iron, and alpha1-antitrypsin, an acute phase reactant that inhibits serum proteases. The gamma globulin fraction is almost entirely composed of immunoglobulins.
accelerator globulin factor V, one of the coagulation factors.
antihemophilic globulin (AHG) factor VIII, one of the coagulation factors.
antilymphocyte globulin (ALG) the gamma globulin fraction of antilymphocyte serum; used as an immunosuppressant in organ transplantation. The term is sometimes used interchangeably with antithymocyte globulin.
antithymocyte globulin (ATG) the gamma globulin fraction of antiserum derived from animals (such as rabbits) that have been immunized against human thymocytes; an immunosuppressive agent that causes specific destruction of T lymphocytes, used in treatment of allograft rejection. The term is sometimes used interchangeably with antilymphocyte globulin.
bacterial polysaccharide immune globulin (BPIG) a human immune globulin derived from the blood plasma of adult human donors immunized with Haemophilus influenzae type b, pneumococcal, and meningococcal polysaccharide vaccines; used for passive immunization of infants under 18 months of age.
cytomegalovirus immune globulin a purified immunoglobulin derived from pooled adult human plasma selected for high titers of antibody against cytomegalovirus; administered intravenously for treatment and prophylaxis of cytomegalovirus disease in transplant recipients.
gamma globulin
hepatitis B immune globulin (HBIG) a specific immune globulin derived from plasma of human donors with high titers of antibodies against hepatitis B surface antigen (HBsAg); used for postexposure prophylaxis following contact with HBsAg-positive materials, also administered to infants of HBsAg-positive mothers.
hyperimmune globulin any of various immune globulin preparations especially high in antibodies against certain specific diseases.
immune globulin
2. a concentrated preparation containing mostly gamma globulins, predominantly IgG, from a large pool of human donors; used for passive immunization against measles, hepatitis A, and varicella and for treatment of hypogammaglobulinemia or agammaglobulinemia in immunodeficient patients, administered intramuscularly. See also immune g. intravenous (human).
immune globulin intravenous (human) a preparation of immune globulin suitable for intravenous administration; used in the treatment of primary immunodeficiency disorders and idiopathic thrombocytopenic purpura, and as an adjunct in the treatment of Kawasaki disease and the prevention of infections associated with chronic lymphocytic leukemia, bone marrow transplantation, and pediatric human immunodeficiency virus infection.
immune human serum globulin immune globulin (def. 2).
immune serum globulin immune g. (def. 2).
pertussis immune globulin a specific immune globulin derived from the blood plasma of human donors immunized with pertussis vaccine; used for the prophylaxis and treatment of pertussis.
rabies immune globulin a specific immune globulin derived from plasma of human donors hyperimmunized with rabies vaccine; administered in conjunction with rabies vaccine in cases of bite or scratch exposure to known or suspected rabid animals.
respiratory syncytial virus immune globulin intravenous a preparation of immunoglobulin G from pooled adult human plasma selected for high titers of antibodies against respiratory syncytial virus; used for passive immunization of infants and young children.
Rh0(D) immune globulin a specific immune globulin derived from human blood plasma containing antibody to the erythrocyte factor Rh0(D); used to prevent Rh-sensitization of Rh-negative females and thus prevent erythroblastosis fetalis in subsequent pregnancies; administered within 72 hours after exposure to Rh-positive blood resulting from delivery of an Rh-positive child, abortion or miscarriage of an Rh-positive fetus, or transfusion of Rh-positive blood. It is also used as a platelet count stimulator in the treatment of idiopathic thrombocytopenic purpura.
serum g's all plasma proteins except albumin, which is not a globulin, and fibrinogen, which is not in the serum. The serum globulins are subdivided into alpha-, beta-, and gamma-globulins on the basis of their relative electrophoretic mobilities.
specific immune globulin a preparation of immune globulin derived from a donor pool preselected for high antibody titer against a specific antigen, such as hepatitis B immune globulin.
tetanus immune globulin a specific immune globulin derived from the blood plasma of human donors who have been immunized with tetanus toxoid; used in the prophylaxis and treatment of tetanus.
thyronine-binding globulin (TBG) (thyroxine-binding globulin) an acidic glycoprotein that is the main binding protein in the blood for thyroxine, and less firmly for triiodothyronine.
vaccinia immune globulin a specific immune globulin derived from the blood plasma of human donors who have been immunized with vaccinia virus smallpox vaccine; used as a passive immunizing agent.
varicella-zoster immune globulin (VZIG) a specific immune globulin derived from plasma of human donors with high titers of varicella-zoster antibodies; used for prevention or amelioration of varicella in immunocompromised patients exposed to the disease and in neonates whose mothers develop varicella in the perinatal period.

immune globulin

n.
Globulin from the blood of a person or animal immune to a certain disease, such as measles. Also called immune serum globulin.

Immune globulin

Serum containing antibodies against a specific infection.

globulin

a general term for proteins that are insoluble in water or highly concentrated salt solutions but soluble in moderately concentrated salt solutions. All plasma proteins except albumin and prealbumin are globulins. The plasma globulins can be separated into five fractions by serum protein electrophoresis (SPE). In order of decreasing electrophoretic mobility these fractions are the alpha1, alpha2, beta1 and beta2 globulins, and the gamma globulins.
The globulins include carrier proteins, which transport specific substances; acute phase reactants, which are involved in the inflammatory process; clotting factors; complement components; and immunoglobulins. Examples are transferrin, a beta1 globulin that transports iron, and alpha1-antitrypsin, an acute phase reactant that inhibits serum proteases. The gamma globulin fraction is almost entirely composed of immunoglobulins.

accelerator globulin
a substance present in plasma, but not in serum, that functions in the formation of intrinsic and extrinsic thromboplastin; called also clotting factor V.
antihemophilic globulin (AHG)
clotting factor VIII.
antilymphocyte globulin (ALG)
a substance used as an immunosuppressive agent in organ transplantation, usually in combination with immunosuppressive drugs; it is the gamma globulin fraction of antilymphocyte serum.
immune globulin
a sterile solution containing antibodies normally present in blood, derived from donor animals, sometimes after hyperimmunization with certain microorganisms; used for passive immunization against some infectious diseases and in the treatment of gamma globulin deficiency.
serum globulin
the fraction of proteins precipitated from blood serum by half saturation with ammonium sulfate; the principal groups include the α-, β- and γ-globulins.
References in periodicals archive ?
9 /PRNewswire/ -- RhoGAM(R) Brand, the original Rh immune globulin product, celebrates its 40th year in the marketplace helping Rh-negative women in the prevention of Hemolytic Disease of the Newborn (HDN).
Experience with the use of an investigational F(ab')2 heptavalent bolulism immune globulin of equine origin during an outbreak of Type E botulism in Egypt.
Transfusion services were asked if they routinely recommend the administration of Rh immune globulin to those patients found or known to have a weak D phenotype and who receive various Rh(D)-positive blood components.
In return for this license, Biotest AG will provide ADMA with certain services at no charge and will also compensate ADMA with cash upon the completion of certain milestones as well as pay a royalty based on a percentage of sales of RSV immune globulin in the territory.
HYQVIA is the first subcutaneous immune globulin (IG) treatment approved for PI patients with a dosing regimen requiring only one infusion up to once per month (every three to four weeks) and one injection site per infusion to deliver a full therapeutic dose of IG.
Today, Grifols SA (Grifols), a global healthcare company based in Barcelona, Spain, broke ground on a new 92,000 square foot, intravenous immune globulin (IVIG) production facility at its manufacturing complex in Los Angeles, California.
An immune globulin product approved for the prevention of hepatitis B recurrence following liver transplantation in hepatitis B surface antigen (HBsAg)-positive liver transplant patients, and the first immune globulin product approved for this use, according to the Food and Drug Administration.
ATLANTA -- Intravenous immune globulin should be the primary means of post-exposure prophylaxis among persons at high risk of severe varicella complications if there is a shortage of varicella zoster immune globulin, according to a vote by the Centers for Disease Control and Prevention's Advisory Committee on Immunization Practices.
Public health officials combat it with water chlorination, sewage treatment, educational campaigns for good hygiene (such as hand washing), and the administration of immune globulin (antibodies harvested from survivors of the disease).
ADMA), a late-stage biotechnology company focused on developing specialty immune globulin therapeutics and the commercialization of human plasma, announced it has entered into a $6 million term loan commitment with Hercules Technology Growth Capital, Inc.
MHA), a leading health care services and technology company focused on alternate site health care providers, today announced the launch of the MHA Clinical Therapy Management (CTM) software module for Immune Globulin therapy.
ATLANTA -- Intravenous immune globulin should be the primary means of postexposure prophylaxis among persons at high risk of severe varicella complications if there is a shortage of varicella zoster immune globulin, according to a vote by the Centers for Disease Control and Prevention's Advisory Committee on Immunization Practices.

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