The mucosal immune system improvs the adaptive anti-inflammatory defence to set homeostasis by immune exclusion
mediated by secretory IgA antibodies to the clearance of pathogenic organisms from the mucosal surfaces by way of neutralising toxins and viral particles, inhibiting adherence of pathogens, colonisation and penetration of mucosal surfaces by pathogenic micro-organisms and immunosuppressive ways to limit over-reaction against inoffensive luminal antigens.
Secretory component: a new role in secretory IgA-mediated immune exclusion
In this model, nonneutralizing VP6-specific IgA mAb were protective, but not when administered directly to the gastrointestinal tract, indicating that IgA transcytosis played a prominent role in effective immune exclusion
Indeed, immune exclusion of all insulin precursors by two MoAbs directed against the junction between A chain and C-peptide and the junction between B chain and C-peptide, respectively, leaves insulin as the sole reactant with the MoAb directed against the B chain.
5, column 1) and the concentration of each mixture was measured before immune exclusion (Fig.