FOXP3

(redirected from immune dysregulation, polyendocrinopathy, enteropathy, X-linked)

FOXP3

A gene on chromosome Xp11.23 that encodes a member of the forkhead/winged-helix family of transcriptional regulators.

Molecular pathology
FOXP3 mutations cause immunodeficiency polyendocrinopathy, enteropathy, X-linked syndrome (IPEX) (X-linked autoimmunity-immunodeficiency syndrome).
References in periodicals archive ?
Canioni et al., "Treatment of the immune dysregulation, polyendocrinopathy, enteropathy, X-linked syndrome (IPEX) by allogeneic bone marrow transplantation," The New England Journal of Medicine, vol.
Ramsdell et al., "The immune dysregulation, polyendocrinopathy, enteropathy, X-linked syndrome (IPEX) is caused by mutations of FOXP3," Nature Genetics, vol.
A group of Japanese researchers noted that [CD4.sup.+][CD25.sup.+][CD127.sup.low] T cells isolated from IPEX (Immune dysregulation, Polyendocrinopathy, Enteropathy, X-linked) patients also exhibited appreciable suppressive activity, although less than that exhibited by Treg cells from healthy controls.
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