Immunoglobulin A vasculitis, formerly called Henoch-Schonlein purpura, is an immune complex vasculitis
mainly affecting small vessels.
One of the main areas of revision included the description of 2 pathophysiologically different groups of small vessel vasculitis including immune complex vasculitis and AAV (Table 1).
Nomenclature of Small Vessel Vasculitis (a) Immune Complex Vasculitis ANCA-Associated Vasculitis Anti-C1q vasculitis Microscopic polyangiitis Anti-GBM vasculitis Granulomatosis with Cryoglobulinemic vasculitis polyangiitis IgA vasculitis Eosinophilic granulomatosis Hypocomplementemic with polyangiitis urticarial vasculitis Abbreviations: ANCA, antineutrophil cytoplasmic antibody;GBM, glomerular basement membrane disease;IgA, immunoglobulin A.
Immune complex vasculitis usually has a largely dependent distribution, and the pauci-immune variety has a random distribution.
In vasculitic purpura, it's important to determine the variety of immune complex vasculitis, because IgA-associated vasculitis is more likely than IgG- or IgM-predominant vasculitis to persist, recur, ulcerate, and be associated with systemic disease, he said.
A dependent distribution suggests immune complex vasculitis