Immortalize | definition of immortalize by Medical dictionary
immortalization (redirected from immortalize)
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Conferring on normal cells cultured in vitro the property of an infinite lifespan, as from spontaneous mutation, by exposure to chemical carcinogens, or by viral infection. Immortalization of primary cells in culture is the first of several steps in the expression of transforming genes of DNA tumor viruses, of retrovirus oncogenes, and cellular oncogenes derived from human cancer cells.
immortalization /im·mor·tal·iza·tion/ (ĭmor″tah-lĭ-za´shun) the gaining of immunity to normal limitations on growth or life span, sometimes achieved by animal cells in vitro or by tumor cells.
immortalization A change in a eukaryotic cell line that confers the ability to go on dividing and reproducing indefinitely. Immortalization implies the ability to continue to reform TELOMERES.
immortalization genetic transformation of a cell type into a cell line that can proliferate virtually indefinitely, as in HYBRIDOMA cells for the production of MONOCLONAL ANTIBODIES.
References in periodicals archive
However, it's his work on blood vessels and tumors that may immortalize
More immediately, investigators may immortalize
cells from many tissues by adding the gene for the telomerase component.