immortalization


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im·mor·tal·i·za·tion

(i-mōr'tăl-i-zā'shŭn),
Conferring on normal cells cultured in vitro the property of an infinite lifespan, as from spontaneous mutation, by exposure to chemical carcinogens, or by viral infection. Immortalization of primary cells in culture is the first of several steps in the expression of transforming genes of DNA tumor viruses, of retrovirus oncogenes, and cellular oncogenes derived from human cancer cells.

immortalization

/im·mor·tal·iza·tion/ (ĭmor″tah-lĭ-za´shun) the gaining of immunity to normal limitations on growth or life span, sometimes achieved by animal cells in vitro or by tumor cells.

immortalization

A change in a eukaryotic cell line that confers the ability to go on dividing and reproducing indefinitely. Immortalization implies the ability to continue to reform TELOMERES.

immortalization

genetic transformation of a cell type into a cell line that can proliferate virtually indefinitely, as in HYBRIDOMA cells for the production of MONOCLONAL ANTIBODIES.
References in periodicals archive ?
As exemplar and prototype, Stewart's contribution infuses the understanding of Afrocentric womanism with imperatives to not only regard cognition, impermanent mortality, and immortalization as key elements of Africana womanist agency, but also to secure a place in the curriculum for cyclically reviving the power of Africana women's voices through studying and performing their writing and oratory.
Gray notes that the cult of scientific immortalization is hardly dead in our time.
Normal human cells have low levels of telomerase expression; however, when telomere length reaches a critical point abnormal activation of telomerase can lead to immortalization and uncontrolled proliferation.
Upon Vladimir Lenin's death in 1924, the revolutionary Leonid Krasin established the Immortalization Commission of the book's title to plan Lenin's mausoleum.
Also, it inhibits EBV-induced immortalization of B cells and the proliferation of several tumor B cells (Jagetia and Aggarwall 2007), while stimulating the proliferation of intestinal B cells (Churchill et al.
Conditional immortalization of primary cells by human papillomavirus type 18 E6 and EJ-ras defines an E6 activity in G0/G1 phase which can be substituted for mutations in p53.
One sees print as a tool for the preservation and immortalization of earlier texts, and the other sees it as a means for the dissemination of contemporary works that served as catalysts for cultural and social change.
Sachs confronts the challenge to the suddenly inappropriate closure of the traditional memoriai or gravestone by titling the cycle "Grabschriften in die Luft geschrieben," and then proceeds to confront the complex role of the artist in creating any sort of an immortalization.
Next, in Le catene di Eymerich, the second diegetic level takes the reader to the scene of Nazi eugenics and the production of human pawns for war on the one hand, and the regeneration/ immortalization of Aryan heroes on the other.
The role of the portrait as a means of commemoration and immortalization sheds a wider light on the rising influence of Enlightenment thinkers, the authority of politicians and statesmen, and the new revolutionary heroes emerging during this period of radical change.