immortalization


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im·mor·tal·i·za·tion

(i-mōr'tăl-i-zā'shŭn),
Conferring on normal cells cultured in vitro the property of an infinite lifespan, as from spontaneous mutation, by exposure to chemical carcinogens, or by viral infection. Immortalization of primary cells in culture is the first of several steps in the expression of transforming genes of DNA tumor viruses, of retrovirus oncogenes, and cellular oncogenes derived from human cancer cells.

immortalization

A change in a eukaryotic cell line that confers the ability to go on dividing and reproducing indefinitely. Immortalization implies the ability to continue to reform TELOMERES.

immortalization

genetic transformation of a cell type into a cell line that can proliferate virtually indefinitely, as in HYBRIDOMA cells for the production of MONOCLONAL ANTIBODIES.
References in periodicals archive ?
Aristotle calls this activity "happiness" (eudaimonia, 2001, Nicomachean Ethics X.vi.2), and this happiness is identical with theoria as the true mode of our immortalization.
The self-coronation by Franciscus essentially refutes the symbolic necessity of the patron in the immortalization of the poet.
Taken together, these studies provide significant insight into pathogenic mechanisms which amplify EBV-infected B cell immortalization, constrain maximal host immunity, and facilitate PTLD.
How accepting would Hmong-ancestry populations be with allowing the immortalization of their genetic samples?
The E6 andE7geneproductsare essential in the process of cell transformation and immortalization [28, 30].
E6 and E7 joint expression is necessary and sufficient for the immortalization of primary human keratinocytes in vitro [3].
(3.) John Gray in his recently published book, The Immortalization Commission: Science and the Strange Quest to Cheat Death (Doubleday Canada: 2011), methodically discusses Sidgwick's approach, outlining the prevailing psychology of belief in an afterlife.
Using Medicyte's the upcyte and vericyte technologies, primary cells are driven into proliferation, thus allowing controlled and reversible bypass of cell cycle control mechanisms without inducing immortalization, uncontrolled cell growth or typical phenotype.
The Immortalization Commission: Science and the Strange Quest to Cheat Death, by John Gray, New York: Farrar, Straus and Giroux, 2011, hardcover, 273 pages.
Immortalization by human papilloma-virus type 16 alters retinoid regulation of human ectocervical epithelial cell dif-ferentiation.
The Irish poet William Butler Yeats underwent a related procedure (vasoligation), close enough to Voronoff's to win him the mocking nickname "The Gland Old Man." The English philosopher John Gray has recently published an account (The Immortalization Commission) of certain 19th- and 20th-century seekers of immortality in Britain and Russia.
S100P calcium-binding protein overexpression is associated with immortalization of human breast epithelial cells in vitro and early stages of breast cancer development in vivo.