immediate hypersensitivity reaction


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im·me·di·ate hy·per·sen·si·tiv·i·ty

an exaggerated immune response mediated by mast cell-bound IgE antibodies occurring within minutes after exposing a sensitized individual to the approximate antigen; also called Type I hypersensitivity. Clinical symptoms result from the physiologic effects of preformed or newly generated mediators, including histamine, platelet activating factor, prostaglandins, leukotrienes, bradykinin, tachykinins, and others. The reaction may be localized to specific organ systems or be generalized, leading to anaphylaxis. Symptoms include pruritus, urticaria, angioedema, conjunctivitis, sneezing, rhinorrhea, bronchospasm, hypotension, arrhythmias, and shock. See: allergy.
Farlex Partner Medical Dictionary © Farlex 2012
References in periodicals archive ?
* - P<0,05; ** - P<0,01; *** - P<0,001 Figure 1: Immediate hypersensitivity reaction to Candida allergen on different stages of HIV Immediate hypersensitivity reaction to Candida in HIV AIDS patients I stage 27,0% II stage 33,3% III stage 83,3% Note: Table made from pie chart.
Type I reactions: These are mediated by IgE antibodies and are also known as immediate hypersensitivity reactions. They include anaphylaxis, traditional notions of "allergies" and atopic asthma.
Various immunologic responses are provoked, including immediate hypersensitivity reactions (Gross and Halliwell, 1985) late phase IgE-mediated responses and cutaneous basophil hypersensitivity reactions (Halliwell et al., 1987) and not delayed hypersensitivity (Reedy et al., 2003).
"PPD is implicated in allergic contact dermatitis, but also in immediate hypersensitivity reactions, and it has been implicated as a possible risk factor for a number of cancers," he added.
These metabolites, which include leukotrienes and prostaglandins, are known to be important mediators of immediate hypersensitivity reactions and other allergic conditions as well as osteoarthritis, rheumatoid arthritis, and other inflammatory disorders.

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