immature teratoma

immature teratoma

Adults
A teratoma with both mature elements from all 3 germ-cell layers (ectodermal, mesodermal, and endodermal), and immature (embryonic, not foetal) tissues, most commonly of neural origin, consisting of primitive neurotubules, neuroepithelial rosettes, immature glial elements, immature ependyma, primitive muscle.

Prognosis
Relatively good if under age 15; guarded if adult (see table).

Grade, Immature teratoma
I)  ≤ 1 focus/slide contains immature tissue—low-grade.
II)  2–3 foci contains immature tissue—high-grade, adjuvant radiation therapy; survival possible.
III) 4+ foci contains immature tissue—high-grade, adjuvant radiation therapy; prognosis very poor.

Based on any immature tissue on any 1 slide at 40X (low-power field).

Children
Immature teratomas behave differently in children; grading is unnecessary, the only histological predictor of recurrence is the presence of foci of yolk-sac tumour (confirmed by IHC stains for CK, AFP, glypican 3, SALL4); immature neural tissue does not indicate malignancy in immature teratomas of infants as it does in adults.

immature teratoma

Malignant teratoma A teratoma that has mature elements from all 3 germ cell layers–ectodermal, mesodermal, and endodermal, and immature tissues, most commonly of neural origin; the neural tissues in ITs consist of primitive neurotubules, neuroepithelial rosettes, immature glial elements, immature ependyma
References in periodicals archive ?
The differential diagnosis of MA with sarcomatous overgrowth also includes endometrial stromal sarcoma [ESS], immature teratoma, malignant mullerian mixed tumours (MMMT) and pure sarcomas when heterologous elements are present.
Successful infertility treatment following fertility-sparing surgery and chemotherapy for ovarian immature teratoma: a case report and a literature review.
Teratoma can be further classified as mature teratoma (adult-type tissue) and immature teratoma [8].
Two cases (6.45%) constituted germ cell tumours, which included one case of primary thymic germinoma and immature teratoma each respectively.
Hibi, "Precocious puberty in a girl with an hCG-secreting suprasellar immature teratoma. Case report," Journal of Neurosurgery, vol.
Histologically, the tumor was categorized as an immature teratoma, because it contained neural tube (Figure 3(c)), glandular structure (Figure 3(d)), and muscle (Figure 3(e)).
Retroperitoneal lymph node dissection (RPLND) was performed revealing mature and immature teratoma with 60-70% transformation to PNET.
The final pathological diagnosis supported congenital epignathus (immature teratoma) with intracranial extension.
Nonseminoma tumors include yolk sac tumors, embryonal carcinoma, choriocarcinoma, mature and/or immature teratoma, and mixed tumors.
Wetherell, "Mature and immature teratoma: a review of pathological characteristics and treatment options," Medical & Surgical Urology, vol.
Histologically, all the pathology specimens returned with high grade immature teratoma (Figure 2).