immature platelet fraction


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immature platelet fraction

Abbreviation: IPF
The percent of platelets found in the circulating blood that still retains RNA. It is elevated (greater than 12%) in diseases in which platelets are rapidly destroyed after their release from the bone marrow, e.g., disseminated intravascular coagulation (DIC), idiopathic thrombocytopenic purpura (ITP), and thrombotic thrombocytopenic purpura (TTP). These diseases can be distinguished from other thrombocytopenic conditions in which platelet regeneration is slower, e.g., aplastic anemia, liver failure, or kidney failure, because the IPF is usually less than 12% in diseases characterized by bone marrow inactivity or suppression. The IPF is determined using flow cytometry.
See also: fraction
References in periodicals archive ?
The immature platelet fraction: an assessment of its application to a routine clinical laboratory.
Immature platelet fraction as a predictor of platelet recovery following hematopoietic progenitor cell transplantation.
Immature platelet fraction. Immature platelets were first described in 1992 by Ault et a1, (9) who coined the term "reticulated platelets" to describe large platelets with elevated nucleic acid content.
Immature Granulocytes with every RET-He within the Reticulocyte profile and an all-new fluores-cent platelet channel for Immature Platelet Fraction to aid physicians in the differential diagnosis of thrombocytopenia.