Differential and
immature neutrophil counts were performed manually after making suitable thin film smears by senior Lab technician.
Laboratory Characteristics of Study Population Infected (n = 58), Noninfected (n = 32), Laboratory Test Mean (SD) Mean (SD) E-selectin (ng/mL) 156.9 (77.0) 88.8 (47.1) CRP (mg/L), mean (range) 48.0 (0-96) 0.5 (0-48) TLC (1000/mL) 13.8 (9.4) 10.5 (5.1) ANC 6.9 (4.2) 5.2 (2.0) I/T ratio 0.30 (0.17) 0.12 (0.11) Platelet count (1000/mL) 220 (80) 235 (80) Control (n = 30), Laboratory Test Mean (SD) P Value E-selectin (ng/mL) 86.7 (37.4) .001 CRP (mg/L), mean (range) 0 (0-8) .001 TLC (1000/mL) 9.9 (4.5) .07 ANC 4.9 (1.9) .10 I/T ratio 0.12 (0.12) .001 Platelet count (1000/mL) 242 (83) .10 Abbreviations: ANC, absolute neutrophil count; CRP, C-reactive protein; I/T,
immature neutrophil to total leukocytes count; TLC, total leukocytes count.
BeyondSpring reported new data from its clinical program for Plinabulin, which demonstrated a superior immune profile compared to Neulasta based on promyelocytes and
immature neutrophil data from clinical study.
PBS were examined for nucleated red blood cells (N-RBC), total white cell count, total neutrophil count,
immature neutrophil count (Including bands and stabs) and mature neutrophil count.
RBC morphology [greater than]2 +
Immature neutrophil series
Immature neutrophils can make their way to the tumor tissue and make the microenvironment immune-suppressive.
(1) Histiocytoid Sweet syndrome (HSS) is a rare histological variant of acute febrile neutrophilic dermatosis, which is distinguished by dermal infiltration with histiocytoid mononuclear cells, thought to be
immature neutrophils. (2) Etanercept is a recombinant fusion protein that inhibits tumor necrosis factor-a (TNF-[alpha]), a cytokine that acts on several cell types to promote inflammation.
Pugin, "Innate immune functions of
immature neutrophils in patients with sepsis and severe systemic inflammatory response syndrome," Critical Care Medicine, vol.
Indeed, severe posttraumatic inflammation induces a boost in the release of banded and
immature neutrophils into the circulation, leading to bone marrow exhaustion and a compromised immune response, both associated with a poor outcome [21, 23, 24].
Some authors have calculated the I:T ratio taking into account all the
immature neutrophils including band form and obtained the ratio with mature to total neutrophil count, many authors have calculated by taking only the band neutrophil: Total neutrophil ratio wherein only the band neutrophils were considered in the numerator of the ratio.
Immature neutrophils (called blasts, bands or stabs) are not as effective as mature neutrophils.
The presence of
immature neutrophils in the bloodstream is therefore an indication that the body is responding to inflammation, infection, or another stimulus to the bone marrow.
