Increased innate immune system activity demonstrated by imiquimod
is characterized histologically by epidermal invasion by macrophages (mostly neutrophils), and clinically by epidermal erosion.
Two separate studies have indicated that 75%-80% of subjects achieve complete clearing after an initial 16-week course of imiquimod
; 59%-75% of recurrences will clear with another 16-week course of treatment with imiquimod
Nestle, "TLRs to cytokines: mechanistic insights from the imiquimod
mouse model of psoriasis," European Journal of Immunology, vol.
The existing treatment modalities including intralesional steroids, cryotherapy, silicone gel sheets, imiquimod
, verapamil and high dose 5-FU have not shown to be very effective and there are only a few clinical studies using low dose 5-FU for keloids.
Treating protruding infantile hemangiomas with topical imiquimod
5% cream caused severe local reactions and disfiguring scars.
Before ingenol mebutate came on the market, investigators randomized patients with AKs to one of three treatment groups: imiquimod
5% cream, 5-FU 5% ointment, or cryotherapy (Br.
Dermatologists often tweak the frequency of application, she added, and results from some studies suggest that outcomes with imiquimod
are similar to those obtained with 5-FU, while others hint that imiquimod
may provide longer-lasting results.
Actavis Inc's Clindamycin and Tretinoin Gel are the generic version of Ziana and its ANDA for Imiquimod
Cream is a generic version of Zyclara.
As our patient did not accept surgical treatment, we started topical imiquimod
5% cream once daily, 5 days a week.
12 May 2010 - Swedish pharma company Meda AB (STO: MEDA A) said today it has acquired the exclusive European rights to a new formulation of imiquimod
for the treatment of actinic keratosis (AK) from US-based Graceway Pharmaceuticals LLC.
Full prescribing information and patient information for Imiquimod
Cream 5% are available at Fougera's web site, www.fougera.com, or by calling (800) 645-9833.
Though surgical removal of LM is most often used to treat the non-invasive form of the cancer, it can have high local recurrence rates.n two patients who had both LM and LMM, researchers used imiquimod
in conjunction with surgery.