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Mean duration of immobility [Figures 1 and 2] in the control Group (A) was observed to be 175 [+ or -] 22.99 seconds, whereas it was about 130 [+ or -] 15.10 seconds in the Group (B) treated with imipramine 10 mg/kg.
After acclimatization, mice were dosed with either MAE (100, 300, and 1000 mg [kg.sup.-1], p.o.), fluoxetine (3, 10, and 30 mg [kg.sup.-1], p.o.), imipramine (10, 30, and 100 mg [kg.sup.-1] p.o.), or 1% tween in distilled water (10 ml [kg.sup.-1] p.o.).
Moreover, joint administration of zinc and imipramine (both in ineffective doses) caused an antidepressant-like effect in the chronic unpredictable stress (CUS) protocol, which is a commonly used preclinical model of depression [14].
(95) In the neoestriate and LC, imipramine, clomipramine or desipramine reduce (20-40%) [G.sub.[alpha]s] immunoreactivity.
This symptom also regressed after giving Imipramine, which is a noradrenergic reuptake inhibitor.
(15) Imipramine has important adverse effects, and overdose can be lethal.
and imipramine in the treatment of mild to moderate depression: a pilot double-blind randomized trial [ISRCTN45683816].
In past studies in which the imipramine toxicity rate on liver was done, it was stated that imipramine causes damage to the liver, and in severe conditions requires transplant [23].
We previously reported the similar effect of imipramine [9], whereas the index became worse in water-administered animals with depression.
TABLE Rates of sexual dysfunction with antidepressant medications (1) Patients with sexual Number dysfunction OR (vs Class Drug of patients (%) placebo) Placebo 605 14.2 -- SSRI Citalopram 654 78.6 20.3 * Escitalopram 305 37.0 3.4 * Fluoxetine 1718 70.6 15.6 * Fluvoxamine 244 25.8 3.27 * Paroxetine 1261 71.5 16.9 * Sertraline 970 80.3 27.4 * SNRI Duloxetine 274 41.6 4.3 * Venlafaxine 610 79.8 24.8 * TCA Imipramine 54 44.4 7.2 * [alpha]-2 Mirtazapine 49 24.5 2.3 antagonist NDRI Bupropion 645 10.4 0.8 NDRI, norepinephrine/dopamine reuptake inhibitor; OR, odds ratio; SNRI, serotonin/norepinephrine reuptake inhibitor; SSRI, selective serotonin reuptake inhibitor; TCA, tricyclic antidepressant.
The antidepressants tested were imipramine, which modulates the activity of certain hormones causing mood disorders; and promethazine, a sedative, antiemetic, and antipsychotic drug.