imipenem-cilastatin sodium

imipenem-cilastatin sodium

[im′ipē′nəm sil′əstat′in]
a broad-spectrum parenteral antibiotic.
indications It is prescribed for the treatment of infections caused by susceptible organisms in the lower respiratory or urinary tracts, skin, abdomen, reproductive organs, bones, or joints. It is also used in the treatment of endocarditis and septicemia.
contraindications It is not recommended for children. Caution should be used in administering it to patients with pseudomembranous colitis, hypersensitivity reactions, or a history of seizures.
adverse effects The most common adverse effects are phlebitis, thrombophlebitis, nausea, vomiting, diarrhea, rash, fever, and central nervous system symptoms.
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The patient was intubated and received the administration of vancomycin (1000 mg every 24 h), imipenem-cilastatin sodium (500 mg every 8 h), vasopressor (norepinephrine, 26 [micro]g/min and dopamine, 30 [micro]g/kg/min) and glucocorticoids (hydrocortisone 50 mg every 6 h).
The patient's illness met the criteria for STSS as shown in [Table 1] and poor treatment response was found, including vancomycin, imipenem-cilastatin sodium, and aggressive resuscitation.
Our case underwent the medical examination 3 days after pyrexia and was treated with vancomycin and imipenem-cilastatin sodium empirically which may be not the suggested combination therapy for STSS because of delayed diagnosis, including STSS and SLE.