imipenem


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Related to imipenem: Meropenem, vancomycin

imipenem

 [im″ĭ-pen´em]
a β-lactam antibiotic with a broad spectrum of activity against gram-positive and gram-negative organisms. Because it is metabolized in the kidneys, it is administered with the enzyme inhibitor cilastatin in order to decrease the amount of it that is degraded by an enzyme in the kidneys.

im·i·pen·em

(im'i-pen'em),
A beta-lactam antibiotic derived from thienamycin with broad spectrum activity used, in combination with cilastin, to treat various infections. Classified as a carbapenem antibiotic.

imipenem

/im·i·pen·em/ (im″ĭ-pen´em) a β with a broad spectrum of activity against both gram-positive and gram-negative organisms.

im·i·pen·em

(im'i-pen'em)
A beta-lactam antibiotic derived from thienamycin with broad spectrum activity used, in combination with cilastin, to treat various infections.

imipenem

An ANTIBIOTIC enzyme inhibitor resistant to breakdown by most beta-lactamases. It is active against a wide range of bacteria. The drug is on the WHO official list. A brand name with cilastatin is Primaxin.

im·i·pen·em

(im'i-pen'em)
A β-lactam antibiotic with broad spectrum activity used to treat various infections.

imipenem

one of the carbapenem group of antibiotics which are β-lactamase resistant. It has a very wide spectrum, but is inactivated by renal tubular enzymes and is given in association with cilastatin, which inhibits renal metabolism. Called also thienamycin.
References in periodicals archive ?
Antibiotic therapy that should be given intravenously is high-dose cefoxitin or imipenem for 3 to 6 weeks, together with clarithromycin and intravenous amikacin.
NDM-1] in environmental isolates that were sensitive to imipenem, we randomly selected 20 imipenem-sensitive clinical isolates for [bla.
Amikasin, amoksisilin-klavulanat, gentamisin, imipenem, meropenem, nitrofurantoin, piperasilin-tazobaktam, sefazolin, sefepim, sefoperazon-sulbaktam, sefotaksim, seftazidim, seftriakson, siprofloksasin ve trimetoprim-sulfametoksazole ait direnc oranlari hesaplanmistir.
Imipenem is recommended as a first-line therapy for multidrug-resistant gram-negative bacteria; however, resistance to imipenem has recently emerged (Ardanuy et al.
As the phenotypic screening was negative for detecting MBLs producing isolates, the resistance to imipenem observed in four of them, is more likely due to a decrease in the expression of OprD, an outer membrane protein channel that acts as the passage for imipenem entry in P.
Karthika et al (14) showed that most of the Acinetobacter isolates showed complete or high resistance to imipenem (100%), meropenem (89%), amikacin (80%), cefotaxime (89%) and ciprofloxacin (72%).
aeruginosa isolated from patients on imipenem and piperacillin/tazobactam became resistant to those drugs more than when patients were prescribed amoxicillin-clavulanic acid, ceftazidime, or cefepime.
Randomized, double-blind, multicenter trial comparing clinafloxacin with imipenem as empirical monotherapy for febrile granulocytopenic patients.