imipenem


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Related to imipenem: Meropenem, vancomycin

imipenem

 [im″ĭ-pen´em]
a β-lactam antibiotic with a broad spectrum of activity against gram-positive and gram-negative organisms. Because it is metabolized in the kidneys, it is administered with the enzyme inhibitor cilastatin in order to decrease the amount of it that is degraded by an enzyme in the kidneys.

im·i·pen·em

(im'i-pen'em),
A beta-lactam antibiotic derived from thienamycin with broad spectrum activity used, in combination with cilastin, to treat various infections. Classified as a carbapenem antibiotic.

imipenem

/im·i·pen·em/ (im″ĭ-pen´em) a β with a broad spectrum of activity against both gram-positive and gram-negative organisms.

im·i·pen·em

(im'i-pen'em)
A beta-lactam antibiotic derived from thienamycin with broad spectrum activity used, in combination with cilastin, to treat various infections.

imipenem

An ANTIBIOTIC enzyme inhibitor resistant to breakdown by most beta-lactamases. It is active against a wide range of bacteria. The drug is on the WHO official list. A brand name with cilastatin is Primaxin.

im·i·pen·em

(im'i-pen'em)
A β-lactam antibiotic with broad spectrum activity used to treat various infections.

imipenem

one of the carbapenem group of antibiotics which are β-lactamase resistant. It has a very wide spectrum, but is inactivated by renal tubular enzymes and is given in association with cilastatin, which inhibits renal metabolism. Called also thienamycin.
References in periodicals archive ?
baumannii to the carbapenem, such as imipenem, has been doubled from 30.
06 Total 61 Table 5 Showing Antibiotic Sensitivity Pattern of Isolates in Blood Culture to Different Antibiotics Organism Isolated Sensitive (100%) Resistant (100%) Pseudomonas Gentamicin, Cloxacillin, Ampicillin, aeruginosa Imipenem Cotrimoxazole, Cefazolin Proteus spp.
Among them, predominant organisms were Gram-negative bacilli with Pseudomonas (18 isolates) being most common organism with the highest sensitivity to piperacillin + tazobactam, imipenem and amikacin.
Klebsiella had also shown similar pattern of sensitivity only the percentages are lower when considering imipenem 85%, amikacin 70% and tazobactam 70%.
Five children with CRE infection were treated with parenteral colistin (colistimethate sodium, Sanofi), hereafter referred to as colistin) and imipenem combination therapy, and 1 child with colistin and meropenem combination therapy.
2003) who refers to that the resistance of Pseudomonas aeruginosa to the quinolones and imipenem is ~20%-25% while in present study it found to be 0% [25].
Imipenem and Meropenem at 95%were found to be the most sensitive antibiotic which is concordance with Malini et al (10) and Benachinmardi et al (3) Among the Pseudomonas species high levels of resistance were recorded for piperacillin (79.
However, they also discovered that 82% were inhibited by Imipenem while Fluoroquinolone was also found to be effective against 70% of all isolated organisms and Cefoperazone as least effective.
faecium had the following resistance profile: AMPR, IMPR, CNR, SR, SXTR (resistance to ampicillin, imipenem, gentamicin, streptomycin, and trimethoprim/sulfamethoxazole, respectively).
2); however, imipenem and meropenem were significantly associated with the development of imipenem-resistant P.
aerogenes were obtained from two sets of sputum culture, and they were found to be sensitive to amikacin, piperacillin, third-generation cephalosporin, imipenem, ertapenem, and intermittent to ciprofloxacin on hospitalization day 5.
Los antibioticos con mayor sensibilidad (>80%) fueron imipenem, amoxicilina + acido clavulanico, clindamicina, metronidazol, ceftriaxona, doxiciclina y cloranfenicol, mientras que los mayores indices de resistencia se observaron frente a sulfatrimetropin (46.