To the diazonium salt 5, a solution of appropriate amide or iminoderivatives , namely, N-substituted 3-oxo-butanamide, ethyl 3-(substituted imino
) butanoate, or N-alkyl-3-(alkyl imino
)-butanamide in absolute ethanol (10 mL), was added while stirring at a temperature of -4[degrees]C, and the mixture was stirred at room temperature for an additional 3 hours.
The content of imino
acids proline and hydroxyproline of fish collagen is generally lower than that of mammalian collagen .
The determination of hydroxyproline in tissue and protein samples containing small proportions of this imino
analogues of thiazolidinones are less widespread, even the accurate possibility to infer an additional manage for chemical variety and hereby allow of examination of unconjugated regions of a thiazolidinone-based pharmacophore (Laurent et al.
Gelatin with high imino
acids (proline and hydroxyproline) has relatively high gel strength (Cho et al., 2006), due to high hydrogen bonding in gel network (Arnesen and Gildberg, 2007).
Cumming and his team at Merck have now designed an additional imino
heterocycle scaffold and in parallel have worked to further optimize binding interactions in sub-sites adjacent to the catalytic dyad.
Loew (1994).Reaction mechanisms of formaldehyde with endocyclic Imino
groups of nucleic acid bases.
[1.] J F Woessner, The determination of hydroxyproline in tissue and protein samples containing small proportions of this imino
acid, Archives of Biochemistry and Biophysics, 93,440-446, (1961).
Both proline and hydroxyproline stabilize the polyproline II extended conformation of each chain in the triple helix due to the stereo chemical restrictions of the imino