Alpha-2 and imidazoline receptor
agonists: Their pharmacology and therapeutic role.
Based on this context, the aim of this study was to further investigate the antinociceptive mechanism of action of uliginosin B through the combination with different drugs used for treating pain in clinical practice, namely morphine (opioid analgesic), amitriptyline (monoamine uptake inhibitor) and clonidine ([[alpha].sub.2]-adrenergic and imidazoline receptor agonist) in the hot-plate assay, in mice.
The mechanism of action of clonidine is not fully elucidated although it is known that it is an agonist at the [[alpha].sub.2]-adrenergic and imidazoline receptors, suppressing the release of noradrenaline in postganglionic sympathetic nerves and that it decreases plasma concentration of noradrenaline (Brunton et al., 2007).
Early studies using mixed [[alpha].sub.2]-adrenergic and imidazoline receptor
agonists, like clonidine and moxonidine, injected into the lateral and third cerebral ventricles, septal area, lateral preoptic area, and lateral hypothalamus showed that they are effective in inhibiting water and sodium intake induced by different stimuli (1,3-10).
Moxonidine is a selective imidazoline receptor agonist.
Moxonidine is an imidazoline compound which acts on [I.sub.1] imidazoline receptors in the central nervous system to reduce blood pressure.
Nogueira, "Evidence for the involvement of the noradrenergic system, dopaminergic and imidazoline receptors
in the antidepressant-like effect of tramadol in mice," Pharmacology Biochemistry & Behavior, vol.
[10-12] Action of tizanidine on imidazoline receptors
is involved in the supraspinal inhibitory effects on spinal reflexes, and at the spinal level, [alpha]2-adrenoceptors and imidazoline receptors
are involved in the inhibitory effects.
Despite its explanation not being clear yet, it encompasses these [beta]-carbolines' high affinity for imidazoline receptors
, namely [I.sub.2], since another drug selective for these receptors, LSL, obtained a similar effect (Miralles et al, 2005).
His paper was entitled, "Imidazoline receptors
: Improved antiserum-based blood test for depression?
11:15 IMIDAZOLINE RECEPTORS
: IMPROVED ANTISERUM-BASED BLOOD TEST FOR DEPRESSION?
Recent studies suggest a role for imidazoline receptors