imidazoles


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Related to imidazoles: clotrimazole, Triazoles

imidazoles

A class of antifungal and antibacterial drugs effective against a wide range of bacteria and fungi. The group includes METRONIDAZOLE (Flagyl), MEBENDAZOLE, THIABENDAZOLE (tiabendazole), CLOTRIMAZOLE (Canesten), ketoconazole and miconazole.

imidazoles

group of topical and systemic broad-spectrum anti-fungal agents; used to treat yeast and dermatophyte infections; see clotrimazole; econazole; ketoconazole; miconazole; and Table 1
Table 1: Treatment of fungal infections of skin and nails
Infection siteAgent
Antimycotic agent (for the treatment of dermatophytosis)
SkinTopical allylamine (e.g. 1% terbinafine cream for 7 days)
Topical imidazoles (e.g. 2% miconazole or 1% clotrimazole for 28 days)
Topical 0.25% amorolfine
Topical 1% econazole
Topical griseofulvin spray (400 μg puff daily for 14 days)
Topical 1% sulconazole
Topical tea tree (manuka) oil
Topical undecenoate (20% zinc undecenoate + 5% undecenoic acid)
Topical Whitfield's ointment (6% benzoic acid + 3% salicylic acid)
Other topicals include: weak iodine solution 2.5%; potassium permanganate paint 1%; salicylate acid cream or alcoholic solution 3-5%; benzoic acid (Whitfield's) ointment; sodium polymetaphosphate dusting powder
Systemic terbinafine (250 mg daily for 2 weeks)
Systemic itraconazole (100 mg daily for 15 days)
Systemic griseofulvin (500 mg daily )
NailTopical amorolfine 0.25% lacquer as an adjunct to systemic treatment
Topical borotannic acid complex acid; Phytex paint (1.46% salicylic acid + 4.89% tannic acid + 3.12% boric acid)
Topical 28% tioconazole lacquer
Topical undecenoate lacquer; Monphytol paint (5% methyl undecenoate + 0.7% propyl undecenoate + 3% salicylic acid + 25% methyl salicylate + 5% propyl salicylate + 3% chlorambucil)
Other topicals: strong iodine 10% solution
Systemic terbinafine (250 mg daily for 12-16 weeks)
Systemic itraconazole (400 mg for 1 week in a month, repeated overall 3 or 4 times)
Anticandidal agent (for the treatment of candidiasis)
SkinTopical antimycotic creams (1% clotrimazole; 1% econazole; 2% miconazole)
Topical nystatin (100 000 units ± 1% tolnaftate)
Antipityriasis versicolor agent (for the treatment of pityriasis versicolor)
SkinTopical 2% ketoconazole
Topical 2.5% selenium sulphide
Topical antimycotic agents (1% clotrimazole; 1% econazole; 2% miconazole; 1% sulconazole; 1% terbinafine)
Systemic fluconazole/itraconazole/ketoconazole/miconazole/voriconazole

imidazoles

a group of synthetic antifungal agents; includes clotrimazole, miconazole, econazole and ketoconazole.
References in periodicals archive ?
In 1882, Radziszewski and Japp reported the first synthesis of the imidazole from 1,2-dicarbonyl compound, various aldehydes and ammonia, to obtain the 2,4,5triphenylimidazoles [8, 9].
Fluconazole is a triazole antifungal with similar mechanism of action as clotrimazole, an imidazole.
The results of the antimicrobial efficacy of the synthesized 2-substituted-4, 5-diphenyl imidazoles are expressed in Table 1.
Synthesis of 1-[hydrazinyl(phenyl)methyl]-1H-imidazole (1): A mixture of imidazole (0.
The sequential therapy studies all used tinidazole, a relatively new agent in the United States; we don't know whether metronidazole or other imidazoles are as effective.
In Switzerland, three triazoles (terconazole, itraconazole, fluconazole) and eight imidazoles (clotrimazole, miconazole, econazole, ketoconazole, tioconazole, isoconazole, oxiconazole, and fenticonazole) are in use (Documed AG 2002).
The ylides have been shown to undergo diastereoselective cycloaddition reactions to produce novel hexahydropyrrolo-[1, 2-a] imidazoles, of interest (i) as aza-analogues of naturally occurring pyrrolizidines, e.
Oral versus intra-vaginal imidazole and triazole anti-fungal treatment of uncomplicated vulvo-vaginal candidiasis (thrush).
Imidazoles with long pot life, and high HDT, for potting, casting, and encapsulation.
Oral and intravaginal imidazoles are equally effective in the treatment of candidiasis (SOR: A); alternate therapies for resistant cases have been little studied.
Company also offers a wide range of imidazole accelerators, including 2-methylimidazole, 2-ethyl-4-methylimidazole, and 2-phenylimidazole, as well as several developmental imidazoles.
Our data suggest that the bactericidal action of imidazoles such as isoconazole nitrate on gram-positive bacteria is based on the accumulation of reactive oxygen species, said Dr.