In 1882, Radziszewski and Japp reported the first synthesis of the imidazole
from 1,2-dicarbonyl compound, various aldehydes and ammonia, to obtain the 2,4,5triphenylimidazoles [8, 9].
Fluconazole is a triazole antifungal with similar mechanism of action as clotrimazole, an imidazole
The results of the antimicrobial efficacy of the synthesized 2-substituted-4, 5-diphenyl imidazoles
are expressed in Table 1.
Synthesis of 1-[hydrazinyl(phenyl)methyl]-1H-imidazole
(1): A mixture of imidazole
The sequential therapy studies all used tinidazole, a relatively new agent in the United States; we don't know whether metronidazole or other imidazoles
are as effective.
In Switzerland, three triazoles (terconazole, itraconazole, fluconazole) and eight imidazoles
(clotrimazole, miconazole, econazole, ketoconazole, tioconazole, isoconazole, oxiconazole, and fenticonazole) are in use (Documed AG 2002).
The ylides have been shown to undergo diastereoselective cycloaddition reactions to produce novel hexahydropyrrolo-[1, 2-a] imidazoles
, of interest (i) as aza-analogues of naturally occurring pyrrolizidines, e.
Oral versus intra-vaginal imidazole
and triazole anti-fungal treatment of uncomplicated vulvo-vaginal candidiasis (thrush).
with long pot life, and high HDT, for potting, casting, and encapsulation.
Oral and intravaginal imidazoles
are equally effective in the treatment of candidiasis (SOR: A); alternate therapies for resistant cases have been little studied.
Company also offers a wide range of imidazole
accelerators, including 2-methylimidazole, 2-ethyl-4-methylimidazole, and 2-phenylimidazole, as well as several developmental imidazoles
Our data suggest that the bactericidal action of imidazoles
such as isoconazole nitrate on gram-positive bacteria is based on the accumulation of reactive oxygen species, said Dr.