imatinib


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imatinib

 [ĭ-mă´tĭ-nib″]
an inhibitor acting specifically on an abnormal enzyme form that is created by the Philadelphia chromosome abnormality and present in chronic myeloid leukemia. It is used in the treatment of chronic myeloid leukemia during blast crisis, accelerated phase, or chronic phase after failure of interferon-α therapy, administered orally as the mesylate salt.

im·a·tin·ib

(im-ă-tin'ib),
An oral agent important in the treatment of chronic myeloid leukemia and gastrointestinal stromal tumors; a specific inhibitor of the Philadelphia reciprocal chromosome translocation-created protein tyrosine kinase enzyme, which works by blocking rapid growth of the mutant clone of tumor cells.

imatinib

/im·at·i·nib/ (ĭ-mă´tĭ-nib″) an antineoplastic used as the mesylate salt in the treatment of chronic myeloid leukemia, inhibiting an abnormal enzyme form constitutively produced in the disease.

imatinib

(ĭ-măt′ə-nĭb)
n.
A tyrosine kinase inhibitor, C29H31N7O, used in its mesylate form to treat certain types of leukemia and various other diseases.

imatinib

[imă′tĭnib′]
an inhibitor acting specifically on an abnormal enzyme form that is created by the Philadelphia chromosome abnormality and present in chronic myeloid leukemia. It is administered orally as the mesylate salt in the treatment of chronic myeloid leukemia during blast crisis, accelerated phase, or chronic phase after failure of interferon-alpha therapy.
References in periodicals archive ?
These results revealed synergistic effect of guggulsterone and imatinib in inducing apoptosis in K562/IMA cells, by a mechanism involving the inhibition of COX-2 and down-regulation of P-glycoprotein expression.
Patients take imatinib orally, offering hope that an anti-angiogenic treatment could be delivered systemically through tablets rather than by anti-VEGF eye injections.
Adjuvant imatinib therapy was not considered as the prognostic factors revealed a low risk.
Anahtar Kelimeler: Kronik myeloid losemi, Tirozin kinaz inhibitoru, Imatinib, Nilotinib, Dasatinib, Bosutinib, Ponatinib
Adding imatinib mesylate to the drug cisplatin blocks the action of a protein that triggers a cascade of events resulting in death of the immature eggs.
Companies that already placing imatinib equivalent in India will no doubt take advantage of the comparative advantage that is to be already on the market, but this does not preclude other generics also active in other countries of the world, they decide to expand or short to converge on Indian square.
While India avoided patenting imatinib, South Africa granted Novartis an initial patent on imatinib in 1993, which expired last month.
An interesting aspect in the management of PDGFRA rearrangement of HES was the variability of the imatinib dosage.
KIT-negative tumors and those with weak, focal staining for KIT are enriched for PDGFRA mutations (see below) (15) (Figure 1); as a group, KIT-negative GISTs are less responsive to imatinib therapy.
Therefore, imatinib, an inhibitor of KIT that is a platelet-derived growth factor-a (PDGFR-a), came into use as the standard first-line agent for metastatic GIST [1],[2] and sunitinib is used for patients who are imatinib refractory.
Cancer medicines company Mylan NV (Nasdaq:MYL)(TASE:MYL) reported on Friday the availability of Imatinib Mesylate Tablets in 100 mg and 400 mg.