References in periodicals archive
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Adenovirus serotype evolution is driven by illegitimate recombination in the hypervariable regions of the hexon protein.
"Homology-facilitated illegitimate recombination" increased the integration of foreign (nonhomologous) DNA at least 105 fold when it was flanked on one side by a piece of DNA homologous to the recipient genome.
In one embodiment of the invention, expression of an endogenous gene is activated or increased following integration into the cell, by non-homologous or illegitimate recombination, of a regulatory sequence that activates expression of the gene.
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