More than two-thirds (n = 72; 71.3%) of the patients had ileocolonic
disease in resected specimens, with 15 (14.8%) having isolated ileum, 8 (7.9%) isolated colonic, and 5 (4.9%) proximal small bowel involvement.
Shen et al., "Use of infliximab within 3 months of ileocolonic
resection is associated with adverse postoperative outcomes in Crohn's patients," Journal of Gastrointestinal Surgery, vol.
In that study, patients with ileal disease had a 9-fold increased risk (HR = 9.25; 95% CI = 4.10-20.87, P < 0.001) to develop an intestinal complication relative to those with colonic disease, while ileocolonic
CD patients had a 6-fold increased risk (HR = 5.74; 95% CI = 2.33-14.13, P < 0.001) to develop a complication.
We present a case of refractory ileocolonic
Crohn's disease in a 27-year-old female treated with dual ustekinumab and vedolizumab biologic therapy.
Whereas in CD the whole gastrointestinal tract can be affected even if there is a predilection for ileocolonic
involvement, UC is reduced to the caecum, colon, and rectum .
Caption: Figure 1: Gross examination of the ileocolonic
surgical resection specimen revealed extensive fat wrapping and induration of the peri-ileal and pericolonic adipose tissue (a).
The patient was emergently taken for surgical exploration and intussusception reduction and she was found to have ischemia of the right colon and distal ileum necessitating a partial hemicolectomy and resection of the distal ileum with end-to-end ileocolonic
43.4% with azathioprine in ulcerative colitis patients with (5.8% proctitis, inflammatory bowel 43% left colitis disease (IBD) and 51.2% pancolitis), Estrada et al, 2014 56.6% with CD (54% ileitis, 43% ileocolonic
disease, 3% colonic presentation) Azathioprine in the 25 patients were elderly--Is it included, tolerated and is it (7 with Crohn's disease, safe?
demonstrated the presence of MAP in fresh ileocolonic
mucosal biopsies .
Epstein, "Implants of noninvasive papillary urothelial carcinoma in peritoneum and ileocolonic
neobladder: support for 'seed and soil' hypothesis of bladder recurrence," Urology, vol.
Onur et al., "Ileocolonic
involvement in Behccet's disease: endoscopic and histological evaluation," Digestion, vol.
A number of clinical variables have been associated with the subsequent development of poor-outcome CD, notably an initial need for corticosteroids, age <40 years, ileocolonic
location, stricturing behaviour, weight loss >5 kg and perianal disease at diagnosis.