idiotypes


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idiotypes

The molecular structure of the variable region of an IMMUNOGLOBULIN molecule that confers its antigenic specificity.
References in periodicals archive ?
This high anti-P3 idiotype antibody response might be part of a protection mechanism to block self-reactive antibodies.
Our results show that both B-1a and B-2 cells are necessary to induce the anti-P3 idiotype IgG response.
(2003) Idiotype - antiidiotypic relationship of neurotropic autoantibodies in patients with mild closed head injury.
[22.] Abisheva NN, Beduleva LV, Menshikov IV, Ivanov VV (2010) Investigation of the mechanisms on idiotype regulation of the immune response in the experimental model of autoimmune hemolytic anemia in mice.
Also, current results can be taken more seriously when the genotypes are experiencing incremental improvements rather than drastic changes from new idiotypes, management procedures, or disease pressures.
Given that B cells can present their own idiotypes in an HLA-dependent manner, it has been reported that a structural loss of HLA class I and II expression or mutations in HLA classes I and II loci facilitate the immune evasion of B-cell lymphoma cells [31].
He indicated that the variable regions of immunoglobulins (idiotypes) may serve as antigens, and anti-idiotypic immunoglobulins can be produced against them [49].
Both experiements relied on Jerne's network hypothesis -- the idea that the immune system is preprogrammed to be activated by idiotypes, portions of antibodies that control their specificity.
OMT together with US Pfizer (NYSE:PFE) have shown that the platform has a complete immune system with broad antibody repertoire, which generates antibodies with human idiotypes as robustly as a wild-type animals make rat antibodies.
OMT and US Pfizer (NYSE:PFE) have shown that the product has a complete immune system with a broad antibody repertoire and produces antibodies with human idiotypes as well as wild-type animals make rat antibodies.
In some instances, some antibodies, called idiotype antibodies, act as antigens, triggering an immune response similar to that described above.