idiotype


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Related to idiotype: isotype, allotype

id·i·o·type

(id'ē-ō-tīp),
Collection of idiotopes within the variable region that confers on an immunoglobulin molecule an antigenic specificity and is frequently a unique attribute of a given antibody in a given animal. It is the product of a limited number of B lymphocyte clones; also found on the T-cell receptor. See: idiotope.
[idio- + G. typos, model]

idiotype

(ĭd′ē-ə-tīp′)
n.
1. A set of one or more antigenic determinants specific to the variable region of an immunoglobulin molecule.
2. A set of immunoglobin molecules that have the same antigen-binding specificity in their variable regions.

id·i·o·type

(id'ē-ō-tīp)
A determinant that confers on an immunoglobulin molecule an antigenic "individuality" and is frequently a unique attribute of a given antibody in a given animal.
[idio- + G. typos, model]

idiotype

unique part of the variable region of an antibody that can itself act as an antigen for another ANTIBODY. see ANTIIDIOTYPE.

id·i·o·type

(id'ē-ō-tīp)
Collection of idiotopes within the variable region that confers on an immunoglobulin molecule an antigenic specificity and is frequently a unique attribute of a given antibody in a given animal. It is the product of a limited number of B lymphocyte clones.
[idio- + G. typos, model]
References in periodicals archive ?
(2006) Expression of functionally active scFv fragment of idiotype antibodies with beta lactamase activity.
By knowing the landscape of the AMMI parameter space, with the locations of current winners and the regions for potential and even universal new winners, desirable idiotypes can be defined.
Neutralizing ADAs block the idiotype of the drug molecule directly or by steric hindrance, with sufficient strength to interfere with, or eliminate, the activity of the drug.
Instead, they reported that the foreign gene was not turned on in most of the cells, but rather it had somehow influenced the mouse's own genes to mimic the foreign gene's idiotype. In other words, many of the mouse's own genes apparently gained the ability to direct immune-system cells to produce "copycat" antibodies carrying the signature of the inserted gene.
Our results show that both B-1a and B-2 cells are necessary to induce the anti-P3 idiotype IgG response.
Both experiements relied on Jerne's network hypothesis -- the idea that the immune system is preprogrammed to be activated by idiotypes, portions of antibodies that control their specificity.
Under terms of the agreement, Stellar Biotechnologies supplies Keyhole Limpet Hemocyanin (KLH) which is coupled to the idiotype protein produced in tobacco plants.
We hypothesize that the interfering antibody in the Olympus ferritin assay is a natural antiidiotypic antibody that binds to a unique idiotype on the rabbit antihuman ferritin antibody linked to latex (5).
Adler, "Regulation of natural anti-allotype antibody responses by idiotype network-induced auto-antiidiotypic antibodies," Journal of Experimental Medicine, vol.
The fourth point is that interfering antibodies may mimic the antigen itself, mimic the reagent antibodies, or mimic both, e.g., in idiotype network immune response (10-12).
Therefore, the interfering antibodies might be idiotypic antibodies that bind to a unique idiotype present on the Elecsys anti-TSH antibodies but not on the Centaur and Architect antibodies.
Yi, "Optimizing dendritic cell vaccine for immunotherapy in multiple myeloma: tumour lysates are more potent tumour antigens than idiotype protein to promote anti-tumour immunity," Clinical & Experimental Immunology, vol.