idiopathic pulmonary fibrosis

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formation of fibrous tissue; see also fibroid degeneration. adj., adj fibrot´ic.
congenital hepatic fibrosis a developmental disorder of the liver, marked by formation of irregular broad bands of fibrous tissue containing multiple cysts formed by disordered terminal bile ducts, resulting in vascular constriction and portal hypertension.
cystic fibrosis (cystic fibrosis of pancreas) see cystic fibrosis.
diffuse idiopathic interstitial fibrosis (diffuse interstitial pulmonary fibrosis) idiopathic pulmonary fibrosis.
endomyocardial fibrosis an idiopathic type of myocardiopathy that is endemic in various parts of Africa and rarely in other areas, characterized by cardiomegaly, marked thickening of the endocardium with dense white fibrous tissue that may extend to involve the inner myocardium, and by congestive heart failure.
idiopathic pulmonary fibrosis chronic inflammatory progressive fibrosis of the pulmonary alveolar walls, with steadily progressive dyspnea, resulting in death from oxygen lack or right heart failure. Most cases are of unknown origin, although some are thought to result from pneumoconiosis, hypersensitivity pneumonitis, scleroderma, and other diseases.
mediastinal fibrosis development of hard white fibrous tissue in the upper portion of the mediastinum, sometimes obstructing the air passages and large blood vessels; called also fibrosing or fibrous mediastinitis.
periureteral fibrosis retroperitoneal fibrosis.
pleural fibrosis fibrosis of the visceral pleura so that part or all of a lung becomes covered with a plaque or a thick layer of nonexpansible fibrous tissue. The more extensive form is called fibrothorax.
postfibrinous fibrosis that occurring in tissues in which fibrin has been deposited.
proliferative fibrosis that in which the fibrous elements continue to proliferate after the original causative factor has ceased to operate.
pulmonary fibrosis idiopathic pulmonary fibrosis.
retroperitoneal fibrosis deposition of fibrous tissue in the retroperitoneal space, producing vague abdominal discomfort, and often causing blockage of the ureters, with resultant hydronephrosis and impaired renal function, which may result in renal failure. Called also Ormond disease.
fibrosis u´teri a morbid condition characterized by overgrowth of the smooth muscle and increase in the collagenous fibrous tissue of the uterus, producing a thickened, coarse, tough myometrium.
Miller-Keane Encyclopedia and Dictionary of Medicine, Nursing, and Allied Health, Seventh Edition. © 2003 by Saunders, an imprint of Elsevier, Inc. All rights reserved.

id·i·o·path·ic pul·mo·nar·y fi·bro·sis (IPF),

an acute to chronic inflammatory process or interstitial fibrosis of the lung of unknown etiology. seen in association with collagen-vascular diseases.
Farlex Partner Medical Dictionary © Farlex 2012

idiopathic pulmonary fibrosis

Idiopathic interstitial fibrosis of lung Pulmonology An idiopathic condition characterized by scarring and fibrosis of alveolar septae more common in middle-aged men, possibly related to collagen vascular disease, with positive 'rheumatoid' serology Clinical Aggressive–rapid onset of dyspnea, orthopnea, hemoptysis, cyanosis, clubbing of fingers and toes, pulmonary HTN, bibasilar rales, non-productive cough, death in 3-6 yrs Imaging Diffuse reticulonodular infiltrates. See Diffuse interstitial fibrosis, Lymphoid interstitial fibrosis, Usual interstitial fibrosis.
McGraw-Hill Concise Dictionary of Modern Medicine. © 2002 by The McGraw-Hill Companies, Inc.

id·i·o·path·ic pul·mo·nar·y fi·bro·sis

(IPF) (id'ē-ō-path'ik pul'mŏ-nar-ē fī-brō'sis)
Subacute form also called Hamman-Rich syndrome (q.v.); an acute to chronic inflammatory process of the lungs, the healing stage of diffuse alveolar damage or acute interstitial pneumonia, either idiopathic or associated with collagen-vascular diseases.
Synonym(s): cryptogenic fibrosing alveolitis.
Medical Dictionary for the Health Professions and Nursing © Farlex 2012
References in periodicals archive ?
The "Idiopathic Pulmonary Fibrosis Treatment Market" highlights the information about the industries and market, technologies, and abilities over the trends and the developments of the industries.
Viruses in Idiopathic Pulmonary Fibrosis. Etiology and Exacerbation.
Genetic variants associated with susceptibility to idiopathic pulmonary fibrosis in people of European ancestry: A genome-wide association study.
Pulmonary tuberculosis in patients with idiopathic pulmonary fibrosis. Eur J Radiol.
Devine, "Drug treatment of idiopathic pulmonary fibrosis: systematic review and network meta-analysis," Chest, vol.
Idiopathic pulmonary fibrosis. Lancet (London, Engl).
Kawut, "Pulmonary hypertension in idiopathic pulmonary fibrosis," Chest, vol.
The inability to model idiopathic pulmonary fibrosis in the laboratory makes it difficult to study the biology of the disease and design possible treatments.
The report provides comprehensive information on the therapeutics under development for Idiopathic Pulmonary Fibrosis, complete with analysis by stage of development, drug target, mechanism of action (MoA), route of administration (RoA) and molecule type.
Individual chapters describe the unique aspects of lung transplantation for idiopathic pulmonary fibrosis, emphysema, cystic fibrosis, pulmonary hypertension, and connective tissue disorders.
Idiopathic pulmonary fibrosis (IPF) has been described as a condition of "accelerated aging" of the lungs and the prevalence of IPF rises dramatically with age [1].

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