idiopathic midline destructive disease

idiopathic midline destructive disease

Lethal midline granuloma of Stewart A diagnosis of exclusion–criteria, consist of a midline granuloma of unknown etiology which, unlike most granulomas of the midline, are secondary manifestations of a primary process–eg, vasculitis–eg, Wegener's granulomatosis, malignancy–eg, lymphoma, nasal carcinoma, infections–eg, destructive fungal infections in immunocompromised Pts Treatment RT. See Lethal midline granuloma, Midline granuloma.
Idiopathic midline destructive disease
1. Local destruction of upper respiratory tract
.
2. No progression to system disease–average follow-up, 7 years
.
3. Acute/chronic inflammation with variable necrosis, without vasculitis, atypia or malignancy
.
4. No evidence of infection or malignancy  
.
References in periodicals archive ?
(6-8) Many authors once listed polymorphic reticulosis, malignant midline reticulosis, lymphomatoid granulomatosis, malignant destructive granuloma, and idiopathic midline destructive disease as separate entities in the etiology of midfacial necrotizing lesions.
This extensive review covers diagnoses from infection to malignant neoplasm to idiopathic midline destructive disease. Among these differential diagnoses, infectious etiology demands immediate attention for its potentially devastating yet treatable complications, and special stains are needed in some cases to identify the offending microorganisms.

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